北京PF-07220060III期临床试验-一项在 18 岁以上患有 HR 阳性、HER2 阴性晚期/转移性乳腺癌且既往未接受过任何针对晚期/转移性疾病的全身性抗癌治疗的研究参与者中进行的研究药物 PF-07220060 联合来曲唑的研究

登记号	CTR20250627	试验状态	进行中
申请人联系人	孙娟娟	首次公示信息日期	2025-02-24
申请人名称	Pfizer Inc./ 辉瑞投资有限公司/ Pfizer Inc.；Pfizer Limited

登记号	CTR20250627
相关登记号	暂无
药物名称	PF-07220060
药物类型	化学药物
临床申请受理号	企业选择不公示
适应症	激素受体阳性、HER2 阴性晚期/转移性乳腺癌
试验专业题目	一项在 18 岁以上患有激素受体 (HR) 阳性、HER2 阴性晚期/转移性乳腺癌且既往未接受过任何针对晚期/转移性疾病的全身性抗癌治疗的研究参与者中进行的比较 PF-07220060 联合来曲唑与 CDK4/6 抑制剂联合来曲唑的干预性、开放性、随机、多中心、III 期研究（FOURLIGHT-3 研究）
试验通俗题目	一项在 18 岁以上患有 HR 阳性、HER2 阴性晚期/转移性乳腺癌且既往未接受过任何针对晚期/转移性疾病的全身性抗癌治疗的研究参与者中进行的研究药物 PF-07220060 联合来曲唑的研究
试验方案编号	C4391024	方案最新版本号	最终方案
版本日期:	2024-09-03	方案是否为联合用药	否

申请人名称	[["Pfizer Inc."],["辉瑞投资有限公司"],["Pfizer Inc.；Pfizer Limited"]]
联系人姓名	孙娟娟	联系人座机	010-85167069	联系人手机号	18611987184
联系人Email	juanjuan.sun@pfizer.com	联系人邮政地址	北京市-北京市-东城区朝阳门北大街五矿广场B座	联系人邮编	100010

主要目的：比较 PF-07220060 联合来曲唑（A 组）与 CDK4/6i（研究者选择：阿贝西利、哌柏西利或瑞波西利）联合来曲唑（B 组）在无进展生存期 (PFS) 方面的疗效 关键次要目的：比较 A 组与 B 组的总生存期 (OS) 次要目的： 比较 A 组与 B 组的肿瘤控制指标，并评估每个治疗组内的持续缓解时间 比较 A 组与 B 组的安全性和耐受性 评估每个治疗组的健康相关生活质量、疾病治疗相关症状以及总体健康状态的 PRO 评价循环肿瘤 DNA (ctDNA) 水平与临床结局之间的关系 探索性目的： 进一步评价以下一线治疗的 PFS 为指标的疗效 (PFS2) 确定 PF-07220060 与来曲唑联合给药时的血药谷浓度，并在该研究参与者人群中探索暴露量与疗效/安全性之间的关系 评价血浆 ctDNA 中的肿瘤基因改变 评价肿瘤组织中的癌症生物学

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	开放	试验范围	国际多中心试验

年龄	18岁(最小年龄)至 无上限 (最大年龄)
性别	男+女
健康受试者	无
入选标准	[["筛选时 ≥ 18 岁（或按照当地法规确定的最低同意年龄）。 n有关男性（章节 10.4.1）和女性（章节 10.4.2）研究参与者的生殖标准，请参阅附录 4。妊娠期或哺乳期女性以及不愿意或不能遵守避孕要求的 WOCBP 或男性均不能参加研究。n绝经前/围绝经期女性和男性研究参与者必须在研究治疗干预首次给药前接受 LHRH 激动剂治疗（如果尚未进行该治疗），并按照 SoA 和章节 6.9.1.1所述在整个研究期间持续治疗。"],["经组织学检查确诊 BC，并有证据表明为局部晚期或转移性疾病，且无法通过根治性手术切除或放疗治愈。n有记录在案的 ER 阳性和/或 PR 阳性肿瘤（根据当地评估），定义为最近一次肿瘤活检报告（最好是在 a/mBC阶段）显示通过符合当地标准的检测明确 ER 阳性和/或 PR 阳性染色细胞 ≥ 1%。尽管方案程序没有要求，如果既往未在a/mBC阶段进行过活检，则应考虑进行新的活检。n根据 ASCO/CAP 指导原则，有 IHC 检查或原位杂交检查记录证实的 HER2 阴性肿瘤 (Wolff et al, 2023)。"],["既往未接受过任何针对局部晚期或转移性疾病的全身性抗癌治疗。注：筛选前因该疾病而接受 ≤ 2 周 NSAI 且同意立刻开始筛选并在研究治疗开始前终止 NSAI 的患者可以参加研究。"],["任何既往治疗的急性影响缓解至不高于 CTCAE 1 级（据研究者判定不构成安全性风险的 AE 除外）。"],["研究参与者必须有可测量病灶，或仅存在不可测量的骨病灶。可测量和不可测量病灶的定义见 RECIST v1.1。对于既往接受过放疗或其他局部治疗的肿瘤病灶，仅在治疗完成后明确记录到治疗部位发生进展时，才被视为可测量病灶。不可测量的仅骨病灶可能包括以下任何一种：成骨性病灶、无可测量软组织成分的溶骨性病灶、无可测量软组织成分的溶骨-成骨混合性病灶。"],["研究参与者的 ECOG PS 评分必须 ≤ 2。"]]
排除标准	[["可能增加研究参与的风险或（根据研究者判断）可能使研究参与者不适合参加研究的任何医学或精神状况，包括近期（过去一年内）或活动性自杀意念/行为或实验室检查异常。"],["入组前 3 年内患有任何其他活动性恶性肿瘤的研究参与者，但经充分治疗的基底细胞或鳞状细胞皮肤癌、宫颈原位癌或鲍温病除外。入组前 3 年内有其他已治愈癌症史的研究参与者在进入研究前必须与申办者讨论。"],["已知或疑似对 PF-07220060 或其他研究治疗干预中的活性成分/辅料存在超敏反应。"],["短期内有即刻危及生命并发症风险的内脏危象的研究参与者，包括大量未受控制的积液（胸腔、心包和腹膜）、肺淋巴管炎或肝脏受累 > 50% 的研究参与者。"],["当前存在 CNS 转移，或既往有 CNS 转移史。"],["在未压碎、溶解或咀嚼片剂的情况下无法吞咽口服药物。"],["当前使用任何禁用伴随用药，或不愿意或不能使用要求的伴随用药。参见章节 6.9。"],["在任何情况下接受过 PF-07220060 或其他研究性抗癌治疗。"],["既往接受过（新）辅助 ET，且在 ET 治疗期间或末次给药后 12 个月内复发。"],["既往接受过（新）辅助 CDK4/6i，且在 CDK4/6i 治疗期间或末次给药后 12 个月内复发。"],["随机化前 2 周内接受过大手术或放射治疗或未从重大副作用中恢复。"],["在本研究所用的研究治疗干预首次给药前 30 天（或根据当地要求确定）或 5 个半衰期内（以时间较长者为准）接受过研究用药品（药物或疫苗）给药。在参与本研究期间的任何时间参与其他研究用药品（药物或疫苗）的研究。"],["QTcF 间期 > 480 ms 或有 QT 间期延长综合征史。"],["肾功能损害定义为使用 CKD-EPI 公式计算的 eGFR < 45 mL/min/1.73 m2。"],["肝功能障碍，定义为：n总胆红素 ＞ 1.5 × ULN（吉尔伯特综合征除外，总胆红素 ＞ 3 × ULN 和/或直接胆红素 ＞ 1.5 × ULN 为排除标准）nAST ＞ 3 × ULN（如果归因于肝转移，则为 ＞ 5 × ULN）nALT ＞ 3 × ULN（如果归因于肝转移，则为 ＞ 5 × ULN）n碱性磷酸酶 ＞ 2.5 × ULN（如果发生肝脏和/或骨转移，则为 ＞ 5 × ULN）"],["血液学异常，定义为：nANC < 1500/mm3n血小板 < 100,000/mm3n血红蛋白 < 9 g/dL"],["直接参与研究执行的研究中心工作人员及其家人、在其他情况下受研究者监管的研究中心工作人员，以及直接参与本研究执行的申办者和申办者代表员工及其家人。"]]

试验药

[["中文通用名:PF-07220060 英文通用名:PF-07220060 商品名称:NA","剂型:片剂 规格:60片/瓶，100mg/片 用法用量:口服，每日2次，每次3片 用药时程:每周期28天,疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:来曲唑 英文通用名:Letrozole 商品名称:弗隆（Femara）","剂型:片剂 规格:30片/盒，2.5mg/片 用法用量:口服，每天一次，每次一片 用药时程:每周期28天,疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"]] 序号 名称 用法

对照药

[["中文通用名:帕博西尼 英文通用名:Palbociclib 商品名称:爱博新(Ibrance)","剂型:胶囊 规格:23胶囊/瓶，125mg/胶囊 用法用量:口服，每天一次，每次一粒 用药时程:每个周期（28天为一个周期）的第1-21天（连续用药3周/停药1周）疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:帕博西尼 英文通用名:Palbociclib 商品名称:爱博新(Ibrance)","剂型:胶囊 规格:23胶囊/瓶，100mg/胶囊 用法用量:口服，每天一次，每次一粒 用药时程:每个周期（28天为一个周期）的第1-21天（连续用药3周/停药1周）疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:帕博西尼 英文通用名:Palbociclib 商品名称:爱博新(Ibrance)","剂型:胶囊 规格:23胶囊/瓶，75mg/胶囊 用法用量:口服，每天一次，每次一粒 用药时程:每个周期（28天为一个周期）的第1-21天（连续用药3周/停药1周）疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:阿贝西利 英文通用名:Abemaciclib 商品名称:唯择（Verzenio）","剂型:胶囊 规格:14胶囊/瓶，150mg/胶囊 用法用量:口服，每天两次，每次一粒 用药时程:连续用药28天，疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:阿贝西利 英文通用名:Abemaciclib 商品名称:唯择（Verzenio）","剂型:胶囊 规格:14胶囊/瓶，100mg/胶囊 用法用量:口服，每天两次，每次一粒 用药时程:连续用药28天，疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:阿贝西利 英文通用名:Abemaciclib 商品名称:唯择（Verzenio）","剂型:胶囊 规格:14胶囊/瓶，50mg/胶囊 用法用量:口服，每天两次，每次一粒 用药时程:连续用药28天，疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:瑞波西利 英文通用名:Ribociclib 商品名称:凯丽隆（Kisqali）","剂型:胶囊 规格:21胶囊/瓶，200mg/胶囊 用法用量:口服，每天一次，每次3粒 用药时程:每个周期（28天为一个周期）的第1-21天（连续用药3周/停药1周），疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"],["中文通用名:来曲唑 英文通用名:Letrozole 商品名称:弗隆（Femara）","剂型:片剂 规格:30片/盒，2.5mg/片 用法用量:口服，每天一次，每次一片 用药时程:每周期28天，疾病进展及不可接受的毒性等原因会导致永久终止研究治疗干预"]] 序号 名称 用法

主要终点指标及评价时间

[["BICR 评定的 无进展生存期 (PFS)","PFS，定义为从随机化日期到首次记录疾病进展或任何原因导致死亡日期（以先发生者为准）的时间","有效性指标"]] 序号 指标 评价时间 终点指标选择

次要终点指标及评价时间

[["总生存期 (OS)","任何原因导致死亡日期的时间","有效性指标"],["研究者评定的 PFSnBICR 和研究者评定的 ORnBICR 和研究者评定的 DoR nBICR 和研究者评定的 CBR","整个试验过程","有效性指标"],["不良事件 (AE)、任何实验室检查和 ECG 异常的类型、发生率、严重程度（根据 NCI CTCAE v5.0 分级）、严重性以及与研究药物的关系","整个试验过程","安全性指标"],["根据 EORTC QLQ C30 评定的研究参与者报告癌症特定总体健康状态/生活质量、功能和症状较基线的变化n根据 BPI-SF 评定的研究参与者报告疼痛症状较基线的变化","整个试验过程","安全性指标"],["根据 EQ-5D-5L 评定的研究参与者报告总体健康状态较基线的变化n根据 EORTC QLQ C30 评定的研究参与者报告 GHS/QoL 至恶化的时间","整个试验过程","安全性指标"],["根据 EORTC 乳腺癌模块 (BR42) 评定的研究参与者报告癌症特定功能和症状的较基线变化n根据 BPI-SF 评定的研究参与者报告疼痛症状至恶化的时间","整个试验过程","安全性指标"],["根据 EORTC QLQ BR42 评定的研究参与者报告功能和症状量表至恶化的时间 n根据 EORTC 项目库问题 168，出现副作用困扰恶化、改善和无变化的患者比例","整个试验过程","安全性指标"],["血浆 ctDNA 水平较基线的定量变化以及与临床结局的相关性","整个试验过程","有效性指标"]] 序号 指标 评价时间 终点指标选择

1	姓名	徐兵河	学位	医学博士	职称	正高级
	电话	13501028690	Email	xubinghe@medmail.com.cn	邮政地址	北京市-北京市-朝阳区潘家园南里17号
	邮编	100021	单位名称	中国医学科学院肿瘤医院

[["中国医学科学院肿瘤医院","徐兵河","中国","北京市","北京市"],["中山大学肿瘤防治中心、中山大学附属肿瘤医院","王树森","中国","广东省","广州市"],["广西医科大学附属肿瘤医院/广西壮族自治区肿瘤医院","谢伟敏","中国","广西壮族自治区","南宁市"],["临沂市肿瘤医院","王京芬","中国","山东省","临沂市"],["西安交通大学第二附属医院","张淑群","中国","陕西省","西安市"],["西安交通大学第一附属医院","杨谨","中国","陕西省","西安市"],["佛山市第一人民医院","庞丹梅","中国","广东省","佛山市"],["中国医科大学附属第一医院","滕月娥","中国","辽宁省","沈阳市"],["浙江大学医学院附属邵逸夫医院","王林波","中国","浙江省","杭州市"],["安徽省肿瘤医院","周守兵","中国","安徽省","合肥市"],["大连医科大学附属第二医院","李曼","中国","辽宁省","大连市"],["湖南省肿瘤医院","欧阳取长","中国","湖南省","长沙市"],["南昌市第三医院","陈文艳","中国","江西省","南昌市"],["温州医科大学第一附属医院","王瓯晨","中国","浙江省","温州市"],["天津市肿瘤医院（天津医科大学肿瘤医院）","佟仲生","中国","天津市","天津市"],["北京医院","张永强","中国","北京市","北京市"],["北京肿瘤医院","李惠平","中国","北京市","北京市"],["北京大学人民医院（北京大学第二临床医学院）","王殊","中国","北京市","北京市"],["山东第一医科大学附属肿瘤医院（山东省肿瘤防治研究院、山东省肿瘤医院）","王永胜","中国","山东省","济南市"],["南方医科大学南方医院","姚广裕","中国","广东省","广州市"],["南京大学医学院附属鼓楼医院","谢丽","中国","江苏省","南京市"],["福建医科大学附属协和医院","侯培锋","中国","福建省","福州市"],["四川省肿瘤医院","王浩","中国","四川省","成都市"],["哈尔滨医科大学附属肿瘤医院","张清媛","中国","黑龙江省","哈尔滨市"],["湖北省肿瘤医院","吴新红","中国","湖北省","武汉市"],["吉林大学第一医院","吕铮","中国","吉林省","长春市"],["浙江省台州医院","谢伯剑","中国","浙江省","台州市"],["中科技大学同济医学院附属同济医院","熊慧华","中国","湖北省","武汉市"],["复旦大学附属肿瘤医院","王红霞","中国","上海市","上海市"],["浙江省肿瘤医院","王晓稼","中国","浙江省","杭州市"],["云南省肿瘤医院","聂建云","中国","云南省","昆明市"],["郑州大学第一附属医院","宗红","中国","河南省","郑州市"],["华中科技大学同济医学院附属协和医院","赵艳霞","中国","湖北省","武汉市"],["中国医学科学院肿瘤医院深圳医院","杜彩文","中国","广东省","深圳市"],["哈尔滨医科大学附属肿瘤医院","蔡莉","中国","黑龙江省","哈尔滨市"],["中南大学湘雅医院","黄隽","中国","湖南省","长沙市"],["兰州大学第一医院","令晓玲","中国","甘肃省","兰州市"],["ONCOSITE – Centro de Pesquisa Clinica em Oncologia","Franke, Fabio Andre","巴西","RIO GRANDE DO SUL","Ijui"],["FUNDACIóN CENIT PARA LA INVESTIGACIóN EN NEUROCIENCIAS","Casalnuovo, Monica Lis","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","CABA - Capital Federal"],["Clinica Universitaria Reina Fabiola","Bella, Santiago Rafael","阿根廷","CóRDOBA","Cordoba"],["Complex Oncology Center - Shumen","Nikolov, Nikolay Nachkov","保加利亚","SHUMEN","Shumen"],["COIBA","Varela, Mirta Susana","阿根廷","BUENOS AIRES","Berazategui"],["Fakultni nemocnice v Motole","Cmejlova, Vlastimila","捷克共和国","PRAHA 5","Praha 5"],["Instituto Medico de la Fundacion Estudios Clinicos","Garbaos, Gabriel Eduardo","阿根廷","SANTA FE","Rosario"],["Princess Alexandra Hospital","Cuff, Katharine","澳大利亚","QUEENSLAND","Woolloongabba"],["Cross Cancer Institute","Basi, Sanraj","加拿大","ALBERTA","Edmonton"],["Centro Polivalente de Asistencia e Investigacion Clinica – CER San Juan","Puig, Juan Manuel","阿根廷","SAN JUAN","San Juan"],["Jewish General Hospital","Ferrario, Cristiano","加拿大","QUEBEC","Montreal"],["Aarhus Universitetshospital, Skejby","Nielsen, Hanne Melgaard","丹麦","MIDTJYLLAND","Aarhus N"],["AZ Maria Middelares","Gremonprez, Félix Bénédict","比利时","OOST-VLAANDEREN","Gent"],["Multiprofile Hospital for Active Treatment Serdika EOOD","Miteva-Yovcheva, Nadezhda Pencheva","保加利亚","SOFIA (STOLITSA)","Sofia"],["Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD","Popova, Bonka Nikolova","保加利亚","GABROVO","Gabrovo"],["Nemocnice AGEL Novy Jicin a.s.","Tlusty, Vojtech","捷克共和国","MORAVSKOSLEZSKY KRAJ","Novy Jicin"],["Specialized Hospital for Active Treatment of Oncology - Haskovo","Boychev, Stoil","保加利亚","HASKOVO","Haskovo"],["Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syopakeskus)","Karihtala, Peeter","芬兰","UUSIMAA","Helsinki"],["Fundacion Respirar","Fuentes, Christian Sebastian","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Ciudad Autónoma de Buenos Aires"],["Complex Oncology Center - Burgas","Nikolov, Krasimir","保加利亚","BURGAS","Burgas"],["Fakultní nemocnice Brno Bohunice","Kral, Zdenek","捷克共和国","BRNO-MěSTO","Brno"],["Peter MacCallum Cancer Centre","Goel, Shom","澳大利亚","VICTORIA","Melbourne"],["Fakultni nemocnice Kralovske Vinohrady","Soumarova, Renata","捷克共和国","PRAHA 10","Praha 10"],["McGill University Health Centre","Asselah, Jamil","加拿大","QUEBEC","Montréal"],["Centre de Cancérologie du Grand Montpellier","Villanueva, Cristian","法国","LANGUEDOC-ROUSSILLON","Montpellier"],["Sourasky Tel Aviv M.C.","Strulov Shachar, shlomit","以色列","HAMERKAZ","tel aviv"],["Rambam Health Care Campus","Shai, Ayelet","以色列","HEIFA","Haifa"],["Amphia Ziekenhuis, locatie Breda Molengracht","Bakker, Janine","荷兰","NOORD-BRABANT","Breda"],["Borsod-Abaúj-Zemplén Vármegyei Kozponti Kórház és Egyetemi Oktatókórház","Dombovari, Gergely","匈牙利","BORSOD-ABAúJ-ZEMPLéN","Miskolc"],["Spaarne Gasthuis","Beeker, Aart","荷兰","NOORD-HOLLAND","Hoofddorp"],["Facharztzentrum Eppendorf","Goekkurt, Eray","德国","HAMBURG","Hamburg"],["InVO Institut fur Versorgungsforschung in der Onkologie","Weide, Rudolf","德国","RHEINLAND-PFALZ","Koblenz"],["Petz Aladar Egyetemi Oktato Korhaz","Szigeti, András","匈牙利","GYOR-MOSON-SOPRON","Gyor"],["Hospital Universitario Virgen Macarena","Henao Carrasco, Fernando","西班牙","SEVILLA","Sevilla"],["Jeroen Bosch Hospital","Tol, Jolien","荷兰","NOORD-BRABANT","Den Bosch"],["HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO","Ruiz Borrego, Manuel","西班牙","SEVILLA","Sevilla"],["Alexandra General Hospital of Athens","ZAGOURI, FLORA","希腊","ATTIKí","Athens"],["Hospital Clinico San Carlos","Garcia Saenz, Jose Angel","西班牙","MADRID, COMUNIDAD DE","Madrid"],["CHUS - Hospital Clinico Universitario","López López, Rafael","西班牙","A CORUNA [LA CORUNA]","santiago de compostela"],["CHUAC-Complejo Hospitalario Universitario A Coruna","Antolin Novoa, Silvia","西班牙","A CORUNA [LA CORUNA]","A Coruna"],["Meander Medisch Centrum","Baas, Jara","荷兰","UTRECHT","Amersfoort"],["COI Centro Oncologico Internacional S.A.P.I. de C.V.","Garnica Jaliffe, Georgina","墨西哥","DISTRITO FEDERAL","Ciudad de México"],["Hadassah Medical Center","Paluch-Shimon, Shani","以色列","YERUSHALAYIM","Jerusalem"],["Medische Centrum Leeuwarden","Hamming, Lisanne","荷兰","FRYSLAN","Leeuwarden"],["Mexico Centre for Clinical Research","GARCIA MONTES, LIZBETT VANESSA","墨西哥","DISTRITO FEDERAL","Mexico City"],["Instytut Centrum Zdrowia Matki Polki","Kalinka, Ewa","波兰","LODZKIE","Lodz"],["I. Department of Oncology, Comenius University and St. Elisabeth Cancer Institute","Mrinakova, Bela","斯洛伐克","BRATISLAVSKY KRAJ","Bratislava"],["Sheba Medical Center","Sella, Tal","以色列","HAMERKAZ","Ramat Gan"],["BRCR Global Mexico - Guadalajara","Lagunes Munoz, Jose Job","墨西哥","JALISCO","Guadalajara"],["Medeon, s.r.o.","Matejkova, Monika","斯洛伐克","TRNAVSKY KRAJ","Banka"],["Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca","Lozano Mejorada, Rebeca","西班牙","CASTILLA Y LEON","Salamanca"],["Centro de Investigacion Clinica de Oaxaca","Castro Alonso, Francisco Javier","墨西哥","OAXACA","Oaxaca"],["Institut Català d`Oncologia - L`Hospitalet","Pernas Simon, Sonia","西班牙","BARCELONA [BARCELONA]","Hospitalet de Llobregat"],["Hospital Universitari Vall d`Hebron","Bellet Ezquerra, Meritxell","西班牙","BARCELONA [BARCELONA]","Barcelona"],["Hospital Universitario 12 de Octubre","Ciruelos Gil, Eva María","西班牙","MADRID","MADRID"],["Chang Gung Medical Foundation-Linkou Branch","Chen, Shin-Cheh","中国台湾","TAIPEI","Taipei"],["Hospital General Universitario de Elche","Rodriguez-Lescure, Alvaro","西班牙","ALICANTE","Elche"],["HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARANON","Jerez Gilarranz, Yolanda","西班牙","MADRID","Madrid"],["Hospital Universitario Virgen de la Victoria","Pascual López, Javier","西班牙","ANDALUCíA","Malaga"],["Hacettepe Universite Hastaneleri","Aksoy, Sercan","土耳其","ANKARA","Ankara"],["Utah Cancer Specialists","Kendall, Stephan DiSean","美国","UTAH","Salt Lake City"],["Cancer and Blood Specialty Clinic","Abdulla, Nihal Essa","美国","CALIFORNIA","Los Alamitos"],["Rutgers Cancer Institute of New Jersey","George, Mridula Annette","美国","NEW JERSEY","New Brunswick"],["Ironwood Cancer & Research Centers","Iyengar, Tara","美国","ARIZONA","Scottsdale"],["Orchard Healthcare Research Inc.","Oliff, Ira A.","美国","ILLINOIS","Skokie"],["Wilmot Cancer Institute","Dhakal, Ajay","美国","NEW YORK","Rochester"],["Cleveland Clinic Florida","Samuel, Thomas","美国","FLORIDA","Weston"],["Adana Medical Park Seyhan Hastanesi","Sezer, Ahmet","土耳其","ADANA","Adana"],["Highlands Oncology Group","Beck, Joseph Thaddeus","美国","ARKANSAS","Springdale"],["Renown Regional Medical Center","Schwartzberg, Lee","美国","NEVADA","Reno"],["Dana-Farber Cancer Institute","Giordano, Antonio","美国","MASSACHUSETTS","Boston"],["Mid Florida Hematology and Oncology Center","Nair, Santosh","美国","FLORIDA","Orange City"],["National Taiwan University Hospital - Hsinchu branch","Lee, Jih-Hsiang","中国台湾","TAIPEI","Taipei"],["Saint Luke`s Cancer Institute","Pluard, Timothy J.","美国","MISSOURI","Kansas City"],["HOSPITAL CLíNICO S. CECILIO","Blancas López-Barajas, Maria Isabel","西班牙","GRANADA","Granada"],["Sunnybrook Research Institute","Carmona Gonzalez, Carlos Amir","加拿大","ONTARIO","Toronto"],["Seoul National University Bundang Hospital","Kim, Jee Hyun","韩国","KYONGGI-DO","Seongnam-si"],["Asan Medical Center","Kim, Sung-Bae","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Gangnam Severance Hospital, Yonsei University Health System","Kim, Jee Hung","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["The Catholic Univ. of Korea Seoul St. Mary`s Hospital","Lee, Jieun","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["National Cancer Center","Lee, Keun Seok","韩国","KYONGGI-DO","Goyang-si"],["CHA Bundang Medical Center, CHA University","Moon, Yong Wha","韩国","KYONGGI-DO","Seongnam-si"],["Korea University Anam Hospital","Park, Kyong Hwa","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Korea University Guro Hospital","Park, In Hae","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Severance Hospital, Yonsei University Health System","Sohn, Joo Hyuk","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Hospital Santa Rita de Cassia","BERTOLLO, GLAUCIO ANTONIO","巴西","ESPíRITO SANTO","VITORIA"],["Centro Gaúcho Integrado de Oncologia, Hematologia, Ensino e Pesquisa","Kussler, Christina Pimentel Oppermann","巴西","RIO GRANDE DO SUL","Porto Alegre"],["Oncoclínica Oncologistas Associados","ROCHA, CLAUDIO CLAUDIO HENRIQUE","巴西","PIAUI","TERESINA"],["Liga Norte Riograndense Contra o Cancer","Aquino Pimentel, Luciana Carla Martins de","巴西","RIO GRANDE DO NORTE","Natal"],["CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA","Silva, Eduardo Cronemberger","巴西","CEARA","Fortaleza"],["Centro de Oncologia do ABC - CEON+ - Unidade Sao Caetano do Sul","Santi, Patricia Xavier","巴西","SAO PAULO","Sao Caetano do Sul"],["Hospital Alemao Oswaldo Cruz","Exman, Pedro","巴西","SAO PAULO","Sao Paulo"],["Associacao Hospitalar Beneficente Sao Vicente de Paulo","Lazaretti, Nicolas Silva","巴西","RIO GRANDE DO SUL","Passo Fundo"],["Hospital de Cancer de Londrina","Liutti, Vitor Teixeira","巴西","PARANA","Londrina"],["ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO","Testa, Laura","巴西","SAO PAULO","Sao Paulo"],["IBCC - Instituto Brasileiro de Controle do Cancer","Cruz, Felipe José Silva Melo","巴西","SAO PAULO","Sao Paulo"],["National Cheng Kung University Hospital","Chung, Wei-Pang","中国台湾","TAINAN","Tainan"],["Mackay Memorial Hospital","Chang, Yuan-Ching","中国台湾","TAIPEI","Taipei"],["I.A.U VM Medical Park Florya Hastanesi","Cicin, Irfan","土耳其","ISTANBUL","Istanbul"],["Adana City Hospital","Cil, Timucin","土耳其","ADANA","Adana"],["Dicle Universitesi","kaplan, Muhammet Ali","土耳其","DIYARBAKIR","sur"],["TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi","Gumus, Mahmut","土耳其","ISTANBUL","Istanbul"],["Gulhane Egitim Arastirma Hastanesi","Karadurmus, Nuri","土耳其","ANKARA","Ankara"],["Memorial Ankara Hastanesi","Demirci, Umut","土耳其","ANKARA","Ankara"],["CHD Vendee","Priou, Frank","法国","VENDéE","La Roche-sur-Yon"],["OSI BILBAO-BASURTO","GALVE CALVO, ELENA","西班牙","BIZKAIA","Bilbao"],["Hospital Jerez de la Frontera","García Galindo, Regina","西班牙","ANDALUCíA","Jerez de la Frontera"],["HOSPITAL CLíNIC DE BARCELONA","Schettini, Francesco","西班牙","BARCELONA [BARCELONA]","Barcelona"],["Hospital Clínico Universitario Virgen de la Arrixaca","Alonso Romero, Jose Luis","西班牙","MURCIA, REGIóN DE","EL PALMAR"],["Fundación Instituto Valenciano de Oncología","GUERRERO ZOTANO, ANGEL","西班牙","VALENCIANA, COMUNITAT","València"],["Hospital Beata María Ana","Cortes Castán, Javier","西班牙","MADRID","Madrid"],["MHAT for Women`s Health Nadezhda","Gencheva, Radostina Bozhidarova","保加利亚","SOFIA","Sofia"],["University Specialized Hospital for Active Treatment of Oncology EAD","Konsoulova, Assia Andrianova","保加利亚","SOFIA","Sofia"],["Budapesti Uzsoki Utcai Kórház","Meszaros, Edina","匈牙利","BUDAPEST","Budapest"],["Markhot Ferenc Korhaz","Deme, Daniel","匈牙利","NA","Eger"],["Istituto Europeo di Oncologia IRCCS","Colleoni, Marco Angelo Oscar","意大利","MILANO","Milano"],["Fakultni Thomayerova nemocnice","Kubala, Eugen","捷克共和国","PRAHA 4","Prague"],["Institut Jules Bordet","Ignatiadis, Michail","比利时","BRUXELLES-CAPITALE, RéGION DE","Anderlecht"],["Organizacion Medica de Investigacion","Alfie, Margarita Sonia","阿根廷","CIUDAD AUTóNOMA DE BUENOS AIRES","Buenos Aires"],["Fundación CORI para la Investigación y Prevención del Cáncer","Kaen, Diego Lucas","阿根廷","LA RIOJA","La Rioja"],["Investigaciones Clinicas Moleculares (ICM)","Galanternik, Fernando","阿根廷","NA","CABA"],["Centro Medico Fleischer","Girola, Joaquín","阿根廷","BUENOS AIRES","CABA"],["SUNY Upstate Medical University","Benjamin, Sam","美国","NEW YORK","Syracuse"],["Akademiska sjukhuset","Schiza, Aglaia","瑞典","UPPSALA LAN [SE-03]","Uppsala"],["The Christie NHS Foundation Trust","howell, sacha jon","英国","LANCASHIRE","Manchester"],["Sarah Cannon Research Institute UK","Williams, Anja","英国","LONDON, CITY OF","London"],["Musgrove Park Hospital","Spensley, Saiqa","英国","SOMERSET","Taunton"],["Rigshospitalet","Knop, Ann Soeegaard","丹麦","HOVEDSTADEN","Copenhagen"],["Cryptex Investigación Clínica S.A. de C.V.","Motola Kuba, Daniel","墨西哥","MéXICO","Cuauhtémoc, Ciudad de México"],["INSTITUTO NACIONAL DE CANCEROLOGIA","Flores Diaz, Diana Fabiola","墨西哥","DISTRITO FEDERAL","Mexico City"],["Sakarya Training and Research Hospital","Hacibekiroglu, Ilhan","土耳其","SAKARYA","Korucuk"],["Fondazione Policlinico Universitario Agostino Gemelli IRCCS – Università Cattolica del Sacro Cuore","Palazzo, Antonella","意大利","LAZIO","Roma"],["Samsung Medical Center","Park, Yeon Hee","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["City Hospital, Nottingham University Hospitals NHS Trust","Madhusudan, Srinivasan","英国","ENGLAND","Nottingham"],["Naestved Sygehus","Oestby, Anne-Cathrine","丹麦","SJAELLAND","Naestved"],["Oaxaca Site Management Organization S.C.","Ruiz Cruz, Sandy","墨西哥","OAXACA","Oaxaca de Juarez"],["The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center","Droder, Robert","美国","TEXAS","Tyler"],["Sanatorio de La Mujer","Nasurdi, Cristina Marcela","阿根廷","SANTA FE","Rosario"],["Nemocnica AGEL Komarno","Rosinska, Olga","斯洛伐克","NITRIANSKY KRAJ","Komarno"],["Saint John`s Cancer Institute","Peddi, Parvin F.","美国","CALIFORNIA","Santa Monica"],["Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.","Rusinova, Lenka","斯洛伐克","KOSICKY KRAJ","Michalovce"],["Antwerp University Hospital","Papadimitriou, Konstantinos","比利时","ANTWERPEN","Edegem"],["Universitaetsklinikum Carl Gustav Carus Dresden","Link, Theresa","德国","SACHSEN","Dresden"],["Stanford Cancer Center","Telli, Melinda L.","美国","CALIFORNIA","Palo Alto"],["Stony Brook University","Cohen, Jules","美国","NEW YORK","Stony Brook"],["IRCCS AOU di Bologna","Zamagni, Claudio","意大利","EMILIA-ROMAGNA","Bologna"],["Országos Onkológiai Intézet","Rubovszky, Gabor","匈牙利","BUDAPEST","Budapest"],["University of Chicago Medical Center","Chen, Nan","美国","ILLINOIS","Chicago"],["IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST)","Palleschi, Michela","意大利","EMILIA-ROMAGNA","Meldola"],["Onze Lieve Vrouw Ziekenhuis Aalst","Huygh, Greet","比利时","OOST-VLAANDEREN","Aalst"],["Saint Joseph Hospital – Cancer Centers of Colorado","Diab, Sami","美国","COLORADO","Denver"],["Aalborg Universitetshospital, Syd","Lorincz, Tamas","丹麦","NORDJYLLAND","Aalborg"],["Rabin Medical Center","Yerushalmi, Rinat","以色列","HAMERKAZ","Petah Tikva"],["Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman","Rorive, Andree","比利时","LIèGE","Liege"],["Centre Georges Francois Leclerc","Desmoulins, Isabelle","法国","COTE-D`OR","Dijon"],["Szabolcs Szatmár Bereg Vármegyei Oktatókórház","Wéber, ágnes","匈牙利","SZABOLCS-SZATMáR-BEREG","Nyíregyhaza"],["Ewha Womans University Mokdong Hospital","Lee, Kyoung Eun","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Complex Oncology Center - Plovdiv EOOD","Tomova, Antoaneta","保加利亚","PLOVDIV","Plovdiv"],["Gazi University Health Research and Application Center Gazi Hospital","Yazici, Ozan","土耳其","ANKARA","Ankara"],["UZ Leuven","Han, Sileny","比利时","VLAAMS-BRABANT","Leuven"],["Exelsus - Oncología Clínica","Zarba, Juan Jose","阿根廷","TUCUMáN","Tucuman"],["CARTI Cancer Center","Kuperman, David","美国","ARKANSAS","Little Rock"],["Hospital Sao Lucas da PUCRS","Barrios, Carlos Henrique Escosteguy","巴西","RIO GRANDE DO SUL","Porto Alegre"],["Fundacao Pio XII - Hospital de Cancer de Barretos","Antoniazzi, Augusto Perazzolo","巴西","SAO PAULO","Barretos"],["Instituto D’Or de Pesquisa e Ensino (IDOR) – Filial Salvador","Andrade, Livia","巴西","BAHIA","Salvador"],["Hospital de Base de Sao José do Rio Preto","Guedes, Joao Daniel Cardoso","巴西","SAO PAULO","Sao José do Rio Preto"],["Hospital de Clinicas de Porto Alegre","Rubini Liedke, Pedro Emanuel","巴西","RIO GRANDE DO SUL","Porto Alegre"],["TYKS","Sundvall, Maria","芬兰","VARSINAIS-SUOMI","Turku"],["Vaasan Keskussairaala","Eigeliene, Natalja","芬兰","POHJANMAA","Vaasa"],["Sodersjukhuset","Margolin, Sara","瑞典","STOCKHOLMS LAN [SE-01]","Stockholm"],["University Hospital and UW Health Clinics","Wisinski, Kari","美国","WISCONSIN","Madison"],["Derriford Hospital","Dubey, Sidharth","英国","DEVON","PLYMOUTH"],["University General Hospital of Heraklion","Mavroudis, Dimitrios","希腊","IRAKLEíO","Heraklion Crete"],["Papageorgiou General Hospital of Thessaloniki","Timotheadou, Eleni","希腊","KENTRIKí MAKEDONíA","Thessaloniki"],["centre hospitalier lyon sud","Freyer, Gilles","法国","RHONE-ALPES","Pierre-Benite"],["Azienda Ospedaliero Universitaria Maggiore della Carità","Gennari, Alessandra","意大利","PIEMONTE","novara"],["Masarykuv onkologicky ustav","Halamkova, Jana","捷克共和国","BRNO-MESTO","Brno"],["Mercy Medical Center - Baltimore","Riseberg, David A.","美国","MARYLAND","Baltimore"],["Advocate Lutheran General Hospital","Hallmeyer, Sigrun","美国","ILLINOIS","Park Ridge"],["Bon Secours St. Francis Medical Center","Irvin, William J.","美国","VIRGINIA","Midlothian"],["Lutheran Hospital – Cancer Centers of Colorado","Log, Karng","美国","COLORADO","Golden"],["Filios Alta Medicina S.A. de C.V.","Martinez Rodriguez, Jorge Luis","墨西哥","NUEVO LEóN","MONTERREY"],["Peninsula Health","Potasz, Nicole","澳大利亚","VICTORIA","Frankston"],["Centro de Oncologia - CEON+ - Unidade Sao Caetano do Sul","Cubero, Daniel de Iracema Gomes","巴西","SAO PAULO","Sao Caetano do Sul"],["Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen","Thery, Jean-Christophe","法国","SEINE-MARITIME","Rouen"],["Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie","Kwiatkowski, Mariusz","波兰","ZACHODNIOPOMORSKIE","Koszalin"],["Bialostockie Centrum Onkologii im. M. Sklodowskiej-Curie w Bialymstoku","Czartoryska-Arlukowicz, Bogumila","波兰","PODLASKIE","Bialystok"],["Hospital Arnau de Vilanova","Llombart Cussac, Antonio","西班牙","VALèNCIA","Valencia"],["Anne Arundel Medical Center","Lee, Young Joo","美国","MARYLAND","Annapolis"],["Washington University School of Medicine","Clifton, Katherine","美国","MISSOURI","Saint Louis"],["Cedars-Sinai","Bitar, Jin Sun Lee","美国","CALIFORNIA","Beverly Hills"],["Narodny onkologicky ustav","Oravcova, Eva","斯洛伐克","NA","Bratislava"],["Instituto Nacional de Cancer - INCA","Carneiro, Raíssa Gomes","巴西","RIO DE JANEIRO","Rio de Janeiro"],["Aurora St.Luke South Shore","Polewski, Peter","美国","WISCONSIN","Grafton"],["Taichung Veterans General Hospital","Hung, Chih-Chiang","中国台湾","TAICHUNG","Taichung"],["National Taiwan University Hospital","Lu, Yen-Shen","中国台湾","TAIPEI","Taipei"],["Capio Saint Gorans Sjukhus","Edman Kessler, Luisa","瑞典","STOCKHOLMS LAN [SE-01]","Stockholm"],["Showa University Hospital","Tsurutani, Junji","日本","TOKYO","Shinagawa-ku"],["National Hospital Organization Kyushu Cancer Center","Tokunaga, Eriko","日本","FUKUOKA","Fukuoka"],["Nagoya City University Hospital","Toyama, Tatsuya","日本","AICHI","Nagoya"],["Juntendo University Hospital","Watanabe, Junichiro","日本","TOKYO","Tokyo"],["Okayama University Hospital","Tanioka, Maki","日本","OKAYAMA","Okayama"],["Kanagawa cancer center","Yamashita, Toshinari","日本","KANAGAWA","Yokohama"],["Nagoya University Hospital","Iwase, Madoka","日本","AICHI","Nagoya"],["Gavle Sjukhus","Cikman, Ilke","瑞典","GAVLEBORGS LAN [SE-21]","Gavle"],["Odense Universitetshospital","Roenlev, Jeanette Dupont","丹麦","SYDDANMARK","Odense"],["Gustave Roussy","EL-RASSY, Elie","法国","VAL-DE-MARNE","Villejuif"],["Pratia MCM Krakow","Grela-Wojewoda, Aleksandra","波兰","MALOPOLSKIE","Krakow"],["Europejskie Centrum Zdrowia Otwock Szpital im.F.Chopina","Szczylik, Cezary","波兰","NA","Otwock"],["Hospital Amaral Carvalho","Beato, Patricia Medeiros Milhomem","巴西","SAO PAULO","Jau"],["Santa Casa de Misericordia de Passos","Malta Neto, Natael Ribeiro","巴西","MINAS GERAIS","Passos"],["Instituto Veracruzano en Investigación Clinica S.C.","Viveros Aguilar, Eloina","墨西哥","VERACRUZ","Veracruz"],["Guy`s & St Thomas` NHS Foundation Trust","Sandri, Ines","英国","SOUTHWARK","London"],["Hygeia Hospital","Stavridi, Flora","希腊","ATTIKí","Marousi"],["Townsville Hospital","Tan, Joanne Yue-Ai","澳大利亚","QUEENSLAND","Douglas"],["Centre Oscar Lambret","LAKHDAR, Sarra","法国","Na","Lille"],["HENRI MONDOR HOSPITAL","TOURNIGAND, Christophe","法国","VAL-DE-MARNE","Créteil"],["Azienda Ospedaliera Universitaria Careggi","Meattini, Icro","意大利","TOSCANA","Firenze"],["Tampereen yliopistollinen sairaala","Tanner, Minna","芬兰","PIRKANMAA","Tampere"],["Kumamoto Shinto General Hospital","Osako, Tomofumi","日本","KUMAMOTO","Kumamoto"],["Istituto Oncologico Veneto IRCCS","Guarneri, Valentina","意大利","VENETO","Padova"],["Gemeinschaftspraxis Hamatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf","Illmer, Thomas","德国","SACHSEN","Dresden"],["National Hospital Organization Osaka National Hospital","Yasojima, Hiroyuki","日本","OSAKA","Osaka"],["Hiroshima City Hiroshima Citizens Hospital","Itoh, Mitsuya","日本","HIROSHIMA","Hiroshima"],["Fakultna nemocnica Trnava","Stresko, Marian","斯洛伐克","TRNAVSKY KRAJ","Trnava"],["Houston Methodist Hospital","Mai, Hanh","美国","TEXAS","Houston"],["University of Naples Federico II","Arpino, Grazia","意大利","CAMPANIA","Napoli"],["Perlmutter Cancer Center at NYU Langone Hospital – Long Island","Marks, Douglas","美国","NEW YORK","New York"],["Békés County Central Hospital","Torday, Laszlo","匈牙利","BéKéS","Gyula"],["Winship Cancer Institute, Emory University","Kalinsky, Kevin","美国","GEORGIA","Atlanta"],["Hospital Brasilia","BARROSO DE SOUSA, ROMUALDO","巴西","DISTRITO FEDERAL","Brasília"],["Center Hospital of the National Center for Global Health and Medicine","Shimomura, Akihiko","日本","TOKYO","Shinjuku-ku"],["Koo Foundation Sun Yat-Sen Cancer Center","Chung, Chi-Feng","中国台湾","TAIPEI","Taipei"],["Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest","Arnedos, monica","法国","NA","Bordeaux"],["CRO-IRCCS","Puglisi, Fabio","意大利","FRIULI-VENEZIA GIULIA","Aviano"],["Hospital Universitario HM Sanchinarro","Galán Gramaje, María","西班牙","MADRID, COMUNIDAD DE","Madrid"],["Aidport","Szoszkiewicz, Renata","波兰","NA","Skorzewo"],["Medipol Mega Universite Hastanesi","Bilici, Ahmet","土耳其","ISTANBUL","istanbul"],["Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi","DOGAN, MUTLU","土耳其","ANKARA","Ankara"],["AdventHealth Orlando","Mchayleh, Wassim","美国","FLORIDA","Altamonte Springs"],["Tohoku University Hospital","Miyashita, Minoru","日本","MIYAGI","Sendai"],["Seoul National University Hospital","Im, Seock-Ah","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Satakunnan Keskussairaala","Pulkkanen, Kalevi Juhani","芬兰","SATAKUNTA","Pori"],["Centre Hospitalier de la Cote Basque","Grellety, Thomas","法国","AQUITAINE","BAYONNE"],["Tumor Zentrum Aarau","Popescu, Razvan Andrei","瑞士","AARGAU","Aarau"],["Kantonsspital Winterthur","Mueller, Andreas","瑞士","ZURICH","Winterthur"],["Kantonspital Baden","Leo, Cornelia","瑞士","AARGAU","Baden"],["Inselspital Bern","Bill, Ruben","瑞士","BERNE","Bern"],["Kantonsspital Olten","Uhlmann Nussbaum, Catrina","瑞士","SOLOTHURN","Olten"],["Kantonsspital Graubunden","Schwitter, Michael","瑞士","GRISONS","Chur"],["Kantonsspital Frauenfeld – Spital Thurgau AG","Sell, Wieland","瑞士","THURGAU","Frauenfeld"],["University Hospital Basel","Kurzeder, Christian","瑞士","BASEL-STADT","Basel"],["KSBL","Vetter, Marcus","瑞士","BASEL-LANDSCHAFT","Liestal"],["UniversitatsSpital Zurich","Witzel, Isabell","瑞士","ZURICH","Zurich"],["Maidstone Hospital","Moss, Charlotte","英国","KENT","Maidstone"],["Allina Health Cancer Institute - Abbott Northwestern Hospital","Krie, Amy Kathryn","美国","MINNESOTA","Minneapolis"],["Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.","Piskorski, Wojciech","波兰","MALOPOLSKIE","Krakow"],["Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer","DELEUZE, Antoine","法国","BRETAGNE","Rennes"],["University of North Carolina Medical Center","Abdou, Yara","美国","NORTH CAROLINA","Chapel Hill"],["Szpitale Pomorskie Sp. z o. o.","Danielewicz, Iwona","波兰","POMORSKIE","Gdynia"],["National Cancer Center Hospital East","Naito, Yoichi","日本","CHIBA","Kashiwa"],["Chiba cancer center","Nakamura, Rikiya","日本","CHIBA","Chiba"],["CIPREC","Slutsky, Ezequiel Hernan","阿根廷","CIUDAD AUTONOMA DE BUENOS AIRES","Buenos Aires"],["The Princess Alexandra Hospital NHS Trust","Konstantis, Apostolos","英国","ESSEX","London"],["Real Hospital de Beneficência Portuguesa de Pernambuco","Moura, Jose Fernado do Prado","巴西","PERNAMBUCO","Recife"],["Gunma Prefectural Cancer Center","Fujisawa, Tomomi","日本","GUNMA","Otashi"],["Princess Margaret Cancer Centre","Cescon, David","加拿大","ONTARIO","Toronto"],["National Hospital Organization Hokkaido Cancer Center","Watanabe, Kenichi","日本","HOKKAIDO","Sapporo"],["Aichi Cancer Center Hospital","Hara, Fumikata","日本","AICHI","Chikusa, Nagoya"],["Osaka University Hospital","Yoshinami, Tetsuhiro","日本","OSAKA","Suita"],["Providence Portland Medical Center","Conlin, Alison Katherine","美国","OREGON","Portland"],["Centre Hospitalier de l`Université de Montréal","Ayoub, Jean-Pierre","加拿大","QUEBEC","Montréal"],["USC/Norris Comprehensive Cancer Center","Stewart, Daphne Brooks","美国","CALIFORNIA","Los Angeles"],["Institut de Cancérologie de l`Ouest","Patsouris, Anne","法国","MAINE-ET-LOIRE","Angers"],["Tom Baker Cancer Center","Henning, Jan-Willem Jan-Willem","加拿大","ALBERTA","Calgary"],["Georgetown University Medical Center","Chitalia, Ami","美国","DISTRICT OF COLUMBIA","Washington, DC"],["Dr. Everett Chalmers Regional Hospital","Anan, Ghadeer","加拿大","NEW BRUNSWICK","Fredericton"],["CIUSSS- saguenay-Lac-Saint-Jean","Guimaraes, Jose Luiz Miranda","加拿大","QUEBEC","Chicoutimi"],["Institut de Cancérologie de l`Ouest","Campone, Mario","法国","LOIRE-ATLANTIQUE","Saint Herblain"],["Sundsvalls Sjukhus","Wennstig, Anna-Karin","瑞典","VASTERNORRLANDS LAN [SE-22]","Sundsvall"],["Imperial College Healthcare NHS Trust, Charing Cross Hospital","Kenny, Laura M","英国","ENGLAND","LONDON"],["The Beatson West of Scotland Cancer Centre","Mukherjee, Leena","英国","SCOTLAND","Glasgow"],["Western General Hospital","Oikonomidou, Olga","英国","EDINBURGH, CITY OF","Edinburgh"],["St James`s University Hospital","Twelves, Christopher J.","英国","LEEDS","Leeds"],["Mount Vernon Hospital","Sutherland, Stephanie","英国","ENGLAND","Northwood"],["University Hospital of Southern Denmark, Esbjerg","Donskov, Frede","丹麦","SYDDANMARK","Esbjerg"],["Boca Raton Regional Hospital","Segota, Zdenka Ena","美国","FLORIDA","Boca Raton"],["Ege Universitesi Hastanesi","Gokmen, Erhan","土耳其","IZMIR","Izmir"],["DCH Regional Medical Center","Jahan, Nusrat","美国","ALABAMA","Birmingham"],["Summit Cancer Care DBA Candler Medical Oncology Practice","Taylor, Mark A.","美国","GEORGIA","Savannah"],["Herlev and Gentofte Hospital","Brix, Eva Harder","丹麦","HOVEDSTADEN","Herlev"],["Sahlgrenska Universitetssjukhuset","Karlsson, Per","瑞典","VASTRA GOTALANDS LAN [SE-14]","Goteborg"],["GRAND HOPITAL DE CHARLEROI","Devaux, Alix","比利时","HAINAUT","Charleroi"],["Gachon University Gil Medical Center","Park, Joo-Hwan","韩国","INCHEON-GWANGYEOKSI [INCHEON]","Namdong-gu"],["Kangbuk Samsung Hospital","Lee, Yun-Gyoo","韩国","SEOUL-TEUKBYEOLSI [SEOUL]","Seoul"],["Taipei Veterans General Hospital","Tseng, Ling-Ming","中国台湾","TAIPEI","Taipei"],["Ospedale Isola Tiberina - Gemelli Isola","Bria, Emilio","意大利","LAZIO","Roma"],["MVZ frr Hamatologie und Onkologie","Nusch, Arnd","德国","NORDRHEIN-WESTFALEN","Velbert"],["MVZ frr Hamatologie und Onkologie Ravensburg GmbH Studienzentrum","Decker, Thomas","德国","BADEN-WURTTEMBERG","Ravensburg"],["Edward-Elmhurst Healthcare, Edward Hospital","Baweja, Mansoina","美国","ILLINOIS","Naperville"],["Providence St. Jude Medical Center","Patel, Giribala R.","美国","CALIFORNIA","Fullerton"],["Centrum Onkologii im. Prof. Franciszka Lukaszczyka","Zurawski, Bogdan","波兰","KUJAWSKO-POMORSKIE","Bydgoszcz"],["Baptist MD Anderson Cancer Center","Avila-Lima, Dayra","美国","FLORIDA","Jacksonville"],["Regionalny Szpital Specjalistyczny im. dr. WIadyslawa Biegańskiego","Sadowska, Urszula","波兰","KUJAWSKO-POMORSKIE","Grudziadz"],["Universitatsklinikum Leipzig","Forstmeyer, Dirk","德国","SACHSEN","Leipzig"],["Sygehus Soenderjylland","Jakobsen, Erik Hugger","丹麦","SYDDANMARK","Sonderborg"],["The Royal Cornwall Hospital","Thomson, Alastair","英国","ENGLAND","Truro"],["Wellness Oncology Hematology","Lashkari, Ashkan","美国","CALIFORNIA","West Hills"],["The Cancer Institute Hospital of JFCR","Aoyama, Yosuke","日本","TOKYO","Koto-ku"],["National Cancer Center Hospital","Yonemori, Kan","日本","TOKYO","Tokyo"],["Istituto Nazionale Tumori Regina Elena","Ferretti, Gianluigi","意大利","ROMA","Roma"],["Mount Sinai Cancer Center","Gligich, Oleg","美国","FLORIDA","Miami"],["Churchill Hospital","Levitt, Nicola","英国","OXFORDSHIRE","Oxford"],["The Royal Surrey County Hospital","Koliou, Panagiotis","英国","SURREY","Guildford"],["Agios Savvas Regional Cancer Hospital","Tryfonopoulos, Dimitrios","希腊","ATTIKI","Athens"],["Intermountain Health St. Mary`s Regional Hospital","Swink, Alicia","美国","COLORADO","Grand Junction"],["Denver Health Oncology","West, Heather","美国","COLORADO","Denver"],["Fakultni nemocnice Bulovka","Beran Holeckova, Petra","捷克共和国","PRAHA 8","Praha 8"],["Bozeman Health Deaconess Hospital","Schenk, Kara Mirski","美国","MONTANA","Bozeman"],["Vastmanlands Sjukhus Vasteras","Nilsson, Cecilia","瑞典","VASTMANLANDS LAN [SE-19]","VAosterA￥s"],["Osaka International Cancer Institute","Nakayama, Takahiro","日本","OSAKA","Osaka-shi"],["Royal Blackburn Hospital","Hogg, Martin","英国","ENGLAND","Fulwood"],["Nederlands Kanker Instituut – Antoni van Leeuwenhoek (NKI-AVL)","Dezentje, Vincent","荷兰","ZUID-HOLLAND","Delft"],["VieCuri Medisch Centrum, locatie Venlo","Boon, Eline","荷兰","GELDERLAND","Venlo"],["University Hospital Coventry & Warwickshire","McAvan, Lucy","英国","WARWICKSHIRE","Coventry"],["Karolinska Universitetssjukhuset Solna","Wiklander, Oscar Per Bjorn","瑞典","STOCKHOLMS LAN [SE-01]","Stockholm"],["Lanssjukhuset Ryhov","Engvall, Kristina","瑞典","JONKOPINGS LAN [SE-06]","Jonkoping"],["Boston Medical Center","Oshry, Lauren","美国","MASSACHUSETTS","Boston"],["St. Luke’s Cancer Institute: Boise","Haghighat, Peyman","美国","IDAHO","Boise"],["University of Illinois at Chicago","Danciu, Oana","美国","ILLINOIS","Chicago"],["Oncology Associates of Oregon, P.C.","Wells, Keith","美国","OREGON","Eugene"],["Texas Oncology - Dallas","Osborne, Cynthia Reese Caulfield","美国","TEXAS","Dallas"],["Fakultna nemocnica s poliklinikou Nove Zamky","Demo, Pavol","斯洛伐克","NITRIANSKY KRAJ","Nove Zamky"],["Basavatarakam Indo American Cancer Hospital & Research Institute","MVT, Krishna Mohan","印度","TELANGANA","HYDERABAD"],["Artemis hospital","Tiwari, Priya","印度","HARYANA","Gurugram"],["Apex Wellness Hospital","BONDARDE, SHAILESH ARJUN","印度","MAHARASHTRA","NASHIK"],["Baylor Scott & White Medical Center - Round Rock","Murray, Christal","美国","TEXAS","Round Rock"],["Spandana Oncology Center","Thungappa, Satheesh Chiradoni","印度","KARNATAKA","Bangaluru"],["Sahyadri Hospitals Pvt Ltd","Patil, Tushar Vishvasrao","印度","MAHARASHTRA","Pune"],["Apollo Multispeciality Hospitals limited","Ganguly, Sandip","印度","WEST BENGAL","Kolkata"],["Bhakti Vedanta Hospital and Research Institute","Raut, Nirmal Vivek","印度","MAHARASHTRA","Mira Bhayandar"],["Nirmal Hospital Pvt Ltd.","Agarwal, Anshul","印度","GUJARAT","Surat"],["The Clatterbridge Cancer Centre","Ahmed, Eliyaz","英国","NA","Wirral"],["Royal Marsden Hospital (Sutton)","Johnston, Stephen","英国","SURREY","London"],["The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C","Cherian, Mathew A","美国","OHIO","Columbus"],["Virginia Cancer Specialists","Singh, Anmol","美国","VIRGINIA","Gainesville"],["WSD MEDI Clinical sp. z o.o","Konieczna, Aleksandra","波兰","NA","Warszawa"],["Hoag Memorial Hospital Presbyterian","Nangia, Chaitali","美国","CALIFORNIA","Newport Beach"],["Deenanath Mangeshkar Hospital & Research Centre","Hingmire, Sachin Sharadchandra","印度","MAHARASHTRA","Pune"],["Sutter Health - Sutter Institute for Medical Research","Rohatgi, Nitin","美国","CALIFORNIA","Sacramento"],["Rajiv Gandhi Cancer Institute And Research Centre","Doval, Dinesh","印度","DELHI","New Delhi"],["Kyoto University Hospital","Masuda, Norikazu","日本","KYOTO","Kyoto"],["CHUV (centre hospitalier universitaire Vaudois)","Zaman, Khalil","瑞士","VAUD","Lausanne"],["Mater Private Hospital - Dublin","Kelly, Catherine Margaret","爱尔兰","DUBLIN","Dublin"],["Beaumont Hospital, Dublin","Morris, Patrick","爱尔兰","DUBLIN","Dublin"],["ICEGCLINIC","Celedon Arrieta, Paola","智利","REGION METROPOLITANA DE SANTIAGO","Santiago"],["St. Vincent`s University Hospital","Walshe, Janice","爱尔兰","DUBLIN","Dublin"],["Bradfordhill","Gallardo, Carlos","智利","REGION METROPOLITANA DE SANTIAGO","Recoleta"],["ONCOCENTRO APYS","Acevedo, Alejandro","智利","VALPARAISO","Vina del Mar"],["FALP","Reyes, Felipe","智利","REGION METROPOLITANA DE SANTIAGO","Santiago"],["CECIM","Bernaschina Olivares, Marco","智利","REGION METROPOLITANA DE SANTIAGO","Santiago"],["IC La Serena Research","Morales, Luisa Elena","智利","COQUIMBO","La Serena"],["Oncovida","Zwenger Kloster, Ariel Osvaldo","智利","REGION METROPOLITANA DE SANTIAGO","Providencia"],["CIDO SpA","Rey, Felipe","智利","ARAUCANIA","Temuco"],["University Cancer & Blood Center, LLC","Shepherd, Cynthia","美国","GEORGIA","ATHENS"],["Tata Memorial Centre","Gupta, Sudeep","印度","MAHARASHTRA","Mumbai"],["St. James`s Hospital","Coleman, Niamh","爱尔兰","DUBLIN","Dublin"],["Fresno Clinical Research Center","Ibrahim, Dina","美国","CALIFORNIA","clovis"],["Universitaetsklinikum Erlangen","Fasching, Peter A","德国","BAYERN","Erlangen"],["UCSF Medical Center at Mission Bay","Rugo, Hope S","美国","CALIFORNIA","San Francisco"],["Mater Misericordiae University Hospital","Iqbal, Shahid","爱尔兰","NA","Dublin 7"],["Cork University Hospital","Connolly, Roisin","爱尔兰","CORK","Cork"],["ROYAL MARSDEN HOSPITAL (CHELSEA)","Johnston, Stephen","英国","SURREY","London"],["UCLA Hematology/Oncology – Santa Monica","Sadeghi, Saeed","美国","CALIFORNIA","Santa Monica"],["Hope and Healing Cancer Services","Gundala, Srilata","美国","ILLINOIS","Hinsdale"],["Queen Elizabeth Hospital Birmingham","Rea, Daniel","英国","WARWICKSHIRE","Birmingham"],["City of Hope Comprehensive Cancer Center","Kang, Irene","美国","CALIFORNIA","Duarte"],["University of California Davis (UC Davis) Comprehensive Cancer Center","Arora, Mili","美国","CALIFORNIA","Sacramento"],["Beth Israel Deaconess Medical Center","Wulf, Gerburg","美国","MASSACHUSETTS","Boston"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["中国医学科学院肿瘤医院伦理委员会","同意","2024-11-20"],["中山大学肿瘤防治中心伦理委员会","同意","2025-01-09"],["中国医学科学院肿瘤医院伦理委员会","同意","2025-01-13"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 153 ； 国际: 1020 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 1 ；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：2025-01-06；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：2025-02-03；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；