北京Dexpramipexole片III期临床试验-一项在重度嗜酸性粒细胞性哮喘受试者中评估口服dexpramipexole有效性、安全性和耐受性的研究

登记号	CTR20244124	试验状态	进行中
申请人联系人	王江华	首次公示信息日期	2024-11-05
申请人名称	Areteia Therapeutics, Inc./ 精鼎医药研究开发（上海）有限公司/ Catalent Pharma Solutions, LLC/ Yourway Transport, Inc.

登记号	CTR20244124
相关登记号	暂无
药物名称	Dexpramipexole片
药物类型	化学药物
临床申请受理号	企业选择不公示
适应症	用于成人和≥12岁青少年重度嗜酸性粒细胞性哮喘患者的新型（非甾体类）口服附加维持治疗。
试验专业题目	一项在重度嗜酸性粒细胞性哮喘受试者中评估口服dexpramipexole治疗52周的有效性、安全性和耐受性的随机、双盲、安慰剂对照、平行组研究。
试验通俗题目	一项在重度嗜酸性粒细胞性哮喘受试者中评估口服dexpramipexole有效性、安全性和耐受性的研究
试验方案编号	方案编号：AR-DEX-22-01	方案最新版本号	中国修正案1
版本日期:	2024-05-30	方案是否为联合用药	否

申请人名称	[["Areteia Therapeutics, Inc."],["精鼎医药研究开发（上海）有限公司"],["Catalent Pharma Solutions, LLC"],["Yourway Transport, Inc."]]
联系人姓名	王江华	联系人座机	021-51118324	联系人手机号	15618878402
联系人Email	Julia.Wang@parexel.com	联系人邮政地址	上海市-上海市-中国（上海）自由贸易试验区商城路506号10层ABC单元	联系人邮编	200120

本研究的主要目的是证明dexpramipexole 在减少重度哮喘急性发作方面的有效性。

试验分类	安全性和有效性	试验分期	III期	设计类型	平行分组
随机化	随机化	盲法	双盲	试验范围	国际多中心试验

年龄	12岁(最小年龄)至 无上限 (最大年龄)
性别	男+女
健康受试者	无
入选标准	[["签署知情同意书和儿童版同意书（如适用）。"],["男性或女性，筛选访视1时年龄≥12岁。"],["筛选访视1前，医生诊断为哮喘的时间≥12个月。"],["哮喘治疗，受试者必须满足以下所有要求（a 至c 项）：na. 在筛选访视 1 前至少12 个月定期接受哮喘控制药物中剂量或高剂量ICSn（根据GINA 2021，每日≥ 500 μg 丙酸氟替卡松干粉制剂或临床效果相当n的制剂）的受试者。nb. 在筛选访视 1 前至少3 个月接受过稳定的中剂量或高剂量ICS 治疗。ICSn可包含在ICS/LABA 复方制剂中。每日口服皮质类固醇是允许的合并用药；每日口服皮质类固醇的受试者必须在筛选访视1前的3个月内保持稳定剂量。nc. 需要根据标准治疗实践使用一种或多种额外的日常哮喘控制药物维持治疗；例如LABA、白三烯拮抗剂、茶碱、长效毒蕈碱拮抗剂、色甘酸/奈多罗米。在筛选访视1 前至少3 个月内，必须有稳定剂量的任何其他哮喘控制药物使用记录。"],["在筛选访视2时，pre-BD FEV1占预计值百分比≥40%且<80%（12-17岁受试者<90%）。"],["具有符合以下至少一项标准的可变气流阻塞：na. 筛选访视2时符合支气管扩张剂可逆性标准，表现为吸入400 μg（4揿）albuterol/沙丁胺醇或等同临床药物后15至30分钟，FEV1 改善率≥12%且改善量≥200 mL（12 - 17 岁受试者为≥ 12%且改善量≥ 160 mL）。不符合支气管扩张剂可逆性入选标准但可逆性≥10%且≥ 160 mL 的受试者，可在筛选期间、基线前至少7天的计划外访视时重复进行一次可逆性肺活量测定评估。nb. 筛选访视1前24个月内，有记录显示支气管扩张剂可逆性（根据上述标准）。nc. 筛选访视1前24个月内，有记录显示2 周内最大呼气量变化≥ 20%。nd. 筛选访视1前24个月内，有记录显示连续两次门诊就诊之间FEV1 的气流变异性≥ 20%。ne. 筛选访视1前24个月内，有记录显示气道高反应性（使FEV1下降20%的乙酰甲胆碱激发浓度<8 mg/mL，或其他临床相关支气管激发试验）。"],["筛选访视2时ACQ-6 ≥1.5。"],["在筛选访视1前12个月内，至少有两次需要使用全身性皮质类固醇（肌内注射、静脉注射或口服）治疗的哮喘急性发作史。"],["WOCBP在筛选访视2和基线访视时的尿妊娠试验结果为阴性。"],["10. 从筛选访视1至研究结束访视，有生育能力的女性（WOCBP；月经初潮后）n必须采取以下任一避孕方法：na. 高效避孕方法（经研究者确认）。高效避孕方法包括：真正禁欲、性伴侣n行输精管切除术、Implanon、女性输卵管结扎绝育、任何有效的宫内节育n器（IUD）、IUD/宫内节育系统（IUS）、左炔诺孕酮宫内节育系统或口服n避孕药。或nb. 两种方案允许的避孕方法并用。n无生育能力的女性是指已永久绝育（子宫切除、双侧卵巢切除或双侧输卵管切除）或n绝经后的女性。如果女性在计划的基线访视日期前闭经12个月，且无其他医学原n因，则将其视为绝经后女性。具体的年龄要求如下：nc. 如果<50岁的女性在停止外源性激素治疗后闭经时间≥12个月，且促卵泡激素（FSH）水平在绝经后范围内，则将其视为绝经后女性。nd. 如果≥50岁的女性在停止所有外源性激素治疗后闭经时间≥12个月，则将其视为绝经后女性。"]]
排除标准	[["受试者在筛选访视1前4周至基线访视（含）期间的任何时间出现重度哮喘急性发作（定义为哮喘恶化，导致紧急治疗、因哮喘住院治疗或使用全身性皮质类固醇治疗）。如果受试者在筛选/导入期发生哮喘急性发作，则可继续接受筛选，并在完成口服类固醇疗程或恢复至筛选前访视口服类固醇维持剂量且研究者认为受试者已恢复至基线状态后14天继续接受研究访视。"],["目前确诊的疾病可能会混淆本研究结果的解释，例如过敏性支气管肺曲霉病、嗜酸性肉芽肿性多血管炎、嗜酸性粒细胞性胃肠道疾病、嗜酸性粒细胞增多综合征、慢性阻塞性肺疾病、特发性肺纤维化。"],["呼吸道感染：筛选访视1 前4 周内发生上呼吸道或下呼吸道、鼻窦或中耳感染。"],["对于12 - 17岁受试者，筛选访视1时AEC < 0.15 × 109/L。"],["在筛选访视1前的最后5个月内接受过生物试验药物治疗。在筛选访视1前30天或5个半衰期（以较长者为准）内接受过非生物试验药物治疗。在过去12个月内接受过GSK3511294（长效抗IL-5抗体）治疗。"],["基线访视前 120 天内接受过以下任何单克隆抗体治疗：benralizumab、度普利尤单抗、美泊利珠单抗、reslizumab、奥马珠单抗、tezepelumab或tralokinumab。"],["基线访视前30天内接受过普拉克索（Mirapex&reg;）治疗。"],["筛选访视1 前30天内接受过已知具有中性粒细胞减少症重大风险的选定药物治疗。"],["在筛选访视1前12个月内进行过支气管热成形术，或计划在未来一年内进行支气管热成形术。"],["筛选访视2时体重<40 kg。"],["筛选访视1前12个月内当前吸烟或吸烟史>10包年。吸烟包括烟草、电子烟和/或使用大麻。"],["已知或疑似酗酒或药物滥用。"],["无法控制的重度高血压：尽管接受了抗高血压治疗，但基线访视前收缩压>180 mmHg 或舒张压>110 mmHg。"],["基线访视前5年内有需要手术（不包括局部和局部广泛切除）、放疗和/或全身治疗的恶性肿瘤史"],["有人类免疫缺陷病毒（HIV）感染史或慢性乙型肝炎或丙型肝炎病毒感染史。"],["筛选访视1前24周内诊断为寄生蠕虫感染，且未接受过SoC治疗或SoC治疗无效。"],["可能影响受试者接受研究程序、遵守访视时间表或遵守研究要求能力的医学或其他状况。"],["已知或疑似不依从用药计划。"],["不愿意或不能遵守方案中概述的程序。"],["筛选访视1或筛选访视2时中性粒细胞绝对计数（ANC）< 2.000 × 109/L。"],["肾功能不全， 定义为筛选访视2时估计肾小球滤过率（eGFR）< 60 mL/min/1.73 m2。"],["活动性肝病，定义为目前存在已知的任何肝脏感染性、肿瘤性或代谢性病变，或筛选访视2 时丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）不明原因升高>3 ×正常值上限（ULN）或总胆红素>2 × ULN，且经至少间隔1周重复测量的相关值异常证实。"],["有纽约心脏病学会IV 级心力衰竭病史，或最后已知的左心室射血分数<25%。"],["基线访视前3个月内有主要心血管不良事件（MACE）史。"],["基线访视前3个月内有药物或消融术无法控制的心脏心律失常病史。"],["长QT综合征病史。"],["筛选访视2时，采用Fridericia公式校正的QT间期（QTcF）：男性>450 ms，女性> 470 ms；束支传导阻滞受试者的QTcF ≥480 ms。"],["筛选访视2时静息ECG显示可能干扰QTcF间期变化判读的具有临床意义的异常，包括心率<45 次/分钟（bpm）或>100 bpm。"],["妊娠或哺乳期女性。"],["不愿意在整个研究期间使用可接受的避孕方法（即含杀精剂的避孕套）的男性。"]]

试验药	[["中文通用名:Dexpramipexole片 英文通用名:DexpramipexoleTablets 商品名称:不适用","剂型:片剂 规格:75mg 用法用量:75mg每日两次（BID) 用药时程:52周"],["中文通用名:Dexpramipexole片 英文通用名:DexpramipexoleTablets 商品名称:不适用","剂型:片剂 规格:150mg 用法用量:150mg每日两次（BID) 用药时程:52周"]] 序号 名称 用法
对照药	[["中文通用名:安慰剂片 英文通用名:Placebotablets 商品名称:不适用","剂型:片剂 规格:不适用 用法用量:1片，每日两次（BID）。 用药时程:52周"]] 序号 名称 用法

主要终点指标及评价时间	[["本研究的主要终点是52周内重度哮喘急性发作（AAER）的年发生率。","治疗期间，受试者每4至8周在研究中心接受一次研究评估。第52周后，受试者终止试验用药品治疗，进入最终随访期，并在第56周接受电话访视。","有效性指标"]] 序号 指标 评价时间 终点指标选择
次要终点指标及评价时间	暂未填写此信息 序号 指标 评价时间 终点指标选择

1	姓名	孙永昌	学位	博士	职称	主任医师
	电话	15611963697	Email	suny@bjmu.edu.cn	邮政地址	北京市-北京市-中国北京市海淀区花园北路49号
	邮编	100191	单位名称	北京大学第三医院

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Huber Heights","Choi, Steve","美国","Ohio","Dayton"],["Allervie Clinical Research- Columbus","Chrzanowski, Robert","美国","Georgia","Columbus"],["Allergy & Asthma Specialists, PSC","Clore, Lee S","美国","Owensboro","Kentucky"],["Global Research Associates","Cobiella, Jose","美国","Florida","Homestead"],["University of Iowa","Comellas, Alejandro","美国","Iowa","Iowa City"],["Elite Medical Research","Day, Gustavo","美国","Texas","Dallas"],["De La Cruz Research Center, LLC","De La Cruz, Alejandro E.","美国","Florida","Miami"],["Velocity Clinical Research, Greenville","De La Cruz, Luis","美国","South Carolina","Greenville"],["My Preferred Research","De La Torre, Enrique S","美国","Florida","Miami"],["Southwest Family Medicine Associates Research Department","Dharma, Christette","美国","Texas","Dallas"],["Linfritz Research Institute Inc","Diaz, Ernesto","美国","Florida","Coral Gables"],["Velocity Clinical Research, Columbia","Feldman, Gregory","美国","South Carolina","Columbia"],["WellNow Urgent Care and Research- Springdale","Gatto, Blaise","美国","Ohio","Cincinnati"],["Investigative Clinical Research of Indiana, LLC","Helm, Robert","美国","Indiana","Elwood"],["OK Clinical Research, LLC","Hull, Michael Shane","美国","Oklahoma","Edmond"],["Clinical Research of Gastonia","Jarratt, Mikell","美国","North Carolina","Gastonia"],["Newport Native MD, Inc.","Klein, Ryan","美国","California","Newport Beach"],["Deaconess Clinic, Inc.","Koleilat, Majed","美国","Indiana","Evansville"],["Washington University School of Medicine","Krings, James","美国","Missouri","St. Louis"],["New York Medical College","Krishnan, Sankaran","美国","New York","Valhalla"],["Florida Center for Allergy and Asthma Research (Aventura)","Landman, Jaime","美国","Florida","Aventura"],["WellNow Urgent Care and Research - NY","Lomas, Jeanne","美国","New York","East Amherst"],["Teradan Clinical Trials LLC","Lorch, Daniel","美国","Florida","Brandon"],["New Life Medical Research Center, Inc.","Martinez, Agustin","美国","Florida","Hialeah"],["Chesapeake Clinical Research, Inc.","Matz, Jonathan","美国","Maryland","White Marsh"],["University of Wisconsin, Madison","Moss, Mark","美国","Wisconsin","Madison"],["Monzon Clinical Trials","Orta-Iglesias, Alberto","美国","Florida","Miami"],["Newport Children's Medical Group","Reda, Zacharia","美国","California","Newport Beach"],["Toledo Institute of Clinical Research Inc","Rehman, Syed","美国","Ohio","Toledo"],["Clinical Trial Network (Houston)","Axler, Maxwell","美国","Texas","Houston"],["Florida Center for Allergy and Asthma Research (Miami)","Rodicio, Ileana","美国","Florida","Miami"],["Finlay Medical Research (Miami)","Rodriguez-Ables, Lilia","美国","Florida","Miami"],["New Generation of Medical Research","Ruiz, Karelia","美国","Florida","Hialeah"],["Amarillo Center for Clinical Research","Saadeh, Constantine","美国","Texas","Amarillo"],["Elixia PHC, LLC","Saba, Fadi","美国","Florida","St. Petersburg"],["Renovatio Clinical","Siddiqi, Ather","美国","Texas","The Woodlands"],["Velocity Clinical Research, Spartanburg","Siddiqui, Farhan","美国","South Carolina","Spartanburg"],["Midwest Chest Consultants, PC","Siler, Thomas","美国","Missouri","St. Charles"],["Masters of Clinical Research, Inc.","Sprague, Amy M","美国","Georgia","Augusta"],["Allergy, Asthma and Clinical Research Center","Tarpay, Martha","美国","Oklahoma","Oklahoma City"],["Pioneer Research Solutions Inc. (Houston)","Velazquez, Francisco","美国","Texas","Houston"],["Advanced Pulmonary Research Institute","Warshoff, Neal","美国","Florida","Loxahatchee"],["Clinical Trial Network (Berwyn)","Yallapragada, Rathna","美国","Illinois","Berwyn"],["Advanced Respiratory and Sleep Medicine, PLLC - Huntersville","Stern, Thomas","美国","North Carolina","Huntersville"],["Asthma and Allergy Center of Chicago","Shah, Rachna","美国","Illinois","River Forest"],["Appalachian Clinical Research - Adairsville","Trimble, John","美国","Georgia","Adairsville"],["Onyx Clinical Research (Flint)","Anne, Suresh","美国","Michigan","Flint"],["Tanner Clinic - Layton (Murray)","Firszt, Rafael","美国","Utah","Murray"],["Burke Internal Medicine & Research","Andrawis, Nabil","美国","Virginia","Burke"],["SIMEDHealth, LLC","Elder, Timothy","美国","Florida","Gainesville"],["PURE LLC","Sikand, Vinay","美国","New Jersey","Toms River"],["Sneeze, Wheeze & Itch Associates, LLC","Siri, Dareen","美国","Illinois","Normal"],["CHEAR Center LLC (Elligo SMO)","Bernard, David","美国","New York","Bronx"],["Clinical Research Professionals","Summa, Richard","美国","Missouri","Chesterfield"],["Kern Research, Inc","Tanus, Tonny","美国","California","Bakersfield"],["California Medical Research Associates, Inc","Vadgama, Sanjay","美国","California","Northridge"],["Paradigm Clinical Research (Clininitative)- Redding","Lupercio, Rafael","美国","California","Redding"],["WakeMed Pulmonary & Critical Care","Boole, Lindsay","美国","North Carolina","Raleigh"],["NorthShore University HealthSystem","Mosnaim, Giselle","美国","Illinois","Skokie"],["American Carolina Clinical Research","Eziri, Emeka Michael","美国","North Carolina","Charlotte"],["Montana Medical Research, Inc","Thornblade, Carl","美国","Montana","Missoula"],["Northwell Health Division of Allergy & Immunology","Farzan, Sherry","美国","New York","Great Neck"],["Allianz Research Institute-Pulmonary (California)","Chang, Eduardo","美国","California","Westminster"],["Rutgers University Medical Center Rutgers RWJMS","Panettieri, Reynold","美国","New Jersey","New Brunswick"],["Rochester Regional Health-Allergy","Ramsey, Allison","美国","New York","Rochester"],["Sante Clinical Research","Mohar, Dale","美国","Texas","Kerrville"],["Allianz Research Institute CO, LLC-Pulmonary","Pham, David","美国","Colorado","Aurora"],["Revival Research Institute, LLC (WCG affiliated- Michigan)","Khalil Saad, Abdulhassan","美国","Michigan","Dearborn"],["Gundersen Health System","Mahr, Todd","美国","Wisconsin","LaCrosse"],["East Carolina University-Internal Med-Div of Pulmonary, Critical Care & Sleep Medicine","Dunn, Bryan","美国","North Carolina","Greenville"],["Pulmonary & Sleep Specialists, PLC (with CCT group)","Alsoub, Mohammad","美国","Tennessee","Dickson"],["Imax Clinical Trials, LLC","Morado, Andrew","美国","La Palma","California"],["Somnos Clinical Research","Szalewski, Robert","美国","Nebraska","Lincoln"],["One of a Kind Clinical Research Center CA LLC","Ahn, Sam","美国","California","Napa"],["Golden Touch Clinical Research/Dr. Akoto","Akoto, Richard","美国","Maryland","Takoma Park"],["Maged Ghaly, MD LLC","Elamir, Mazhar","美国","New Jersey","Jersey City"],["RNA America Health Sciences","Faiyaz, Roohi","美国","Georgia","Sugar Hill"],["Onyx Clinical Research (Rochester Hills)","Surendran, Ramkrishna","美国","Michigan","Rochester Hills"],["Axon Clinical Research (Maryland)","Liburd, Joleen","美国","Maryland","Baltimore"],["Exordia Medical Research, INc","Sousa, Daniel","美国","Massachusetts","Fall River"],["Parikh Institute of Research","Parikh, Purvi","美国","New Jersey","Highland Park"],["Alba Clinical Research","Nowins, Rosemary","美国","Nevada","Las Vegas"],["Northwestern University Feinberg school of Medicine","Peters, Anju","美国","Illinois","Chicago"],["University of Utah - Department of Dermatology","Shum, Mili","美国","Utah","Murray"],["Advanced Family Medical Care (ClinCove SMO)","Khan, Ahtaram","美国","Texas","Plano"],["Advanced Pediatrics Research","Ulen, Christina","美国","Virginia","Vienna"],["Shepherd Allergy (ClinCove SMO)","Shepherd, Meagan","美国","West Virginia","Barboursville"],["Henderson Clinical Trials","Sayal, Vikas","美国","Nevada","Henderson"],["Paradigm Clinical Research (SMO)","Jones, Daniel","美国","California","San Diego"],["Anil Dhar Medicine Professional Corporation","Dhar, Anil","加拿大","Ontario","Windsor"],["Dynamic Drug Advancement Ltd","Philteos, George","加拿大","Ontario","Ajax"],["Burlington Lung Clinic (BLC)","Killorn, Patrick","加拿大","Ontario","Burlington"],["Centre for Lung Health","Bergeron, Celine","加拿大","British Columbia","Vancouver"],["Kids Clinic Inc","Khattak, Sohail","加拿大","Ontario","Ajax"],["Research Institute of the McGill University Health Centre","Alizadehfar, Reza","加拿大","Quebec","Montreal"],["St Boniface Hospital Inc.-Respiratory Research","Ramsey, Clare","加拿大","Manitoba","Winnipeg"],["Diex Recherche Trois-Rivières Inc","Gauthier, Patrice","加拿大","Quebec","Trois-Rivieres"],["Recherche Clinique-SIGMA","Chouinard, Guy","加拿大","Quebec","Quebec"],["Woolwich Wellness Weight Loss and Management","Le, Jamie","加拿大","Ontario","Guelph"],["SC Theramed Healthcare SRL","Agache, Ioana","罗马尼亚","Brasov","Brasov"],["SC POLICLINICA DE DIAGNOSTIC RAPID SA","Ciobanu, Cristina Mihaela","罗马尼亚","Brasov","Brasov"],["Spitalul Clinic de Pneumoftiziologie “Leon Daniello”","Domokos, Bianca Gergely","罗马尼亚","Cluj-Napoca","Cluj-Napoca"],["SC ANGISAN SRL","Trailescu, Ana-Maria","罗马尼亚","Ilfov County","Bragadiru"],["Profilaxis","Panaitescu, Carmen","罗马尼亚","Timiè County","Timis"],["Anima Specialty Medical Services SRL","Ciobanu, Magdalena Aurelia","罗马尼亚","Bucharest","Bucuresti"],["Mincu Bogdan-Mihai - Cabinet Medical De Pneumologie","Mincu, Bogdan","罗马尼亚","Cluj-napoca","Cluj-napoca"],["SC Medical Center SRL","Petrui, Ioan-Dorin","罗马尼亚","Hunedoara County","Deva"],["Tower Family Healthcare (NWEH)","Singh, Karishma","英国","Manchester","Bury"],["Ashton Medical Group (NWEH)","Razzaq, Omair","英国","Manchester","Ashton"],["Silverdale Medical Practice (NWEH)","Sharma, Mitesh","英国","Manchester","Swinton"],["Langworthy Medical Practice (NWEH)","Brown, Benjamin","英国","Manchester","Salford"],["Peterloo Medical Centre (NWEH)","Ghafoor, Imran","英国","Manchester","Middleton"],["St Johns Medical Centre (NWEH)","McCune, Lorna","英国","Altrincham","Altrincham"],["Davyhulme Medical Centre (NWEH)","Ashraf, Samina","英国","Manchester","Urmston"],["Northenden Group Practice- Gatley Green Branch Surgery (NWEH)","Wright, Paul","英国","Manchester","Gatley"],["Synexus Lancashire Clinical Research Centre (AES NW Consortium Lancashire)","Glaves, Matthew","英国","Lancashire","Chorley"],["Synexus Scotland Clinical Research Centre (AES Glasgow)","Agarwal, Puneet","英国","Bellshill","Bellshill"],["Synexus Merseyside Clinical Research Centre (AES NW Consortium Merseyside)","Peacey, Kirsten","英国","Liverpool","Liverpool"],["Synexus Manchester Clinical Research Centre (AES NW Consortium Manchester)","Viljoen, Marianne Elizabeth","英国","Manchester","Manchester"],["Synexus Midlands Clinical Research Centre (AES Midlands)","Faulkner, Karen","英国","Birmingham","Birmingham"],["Panthera Biopartners (Enfield)","Avornyo, Anthony","英国","London","London"],["Panthera Biopartners (Preston)","Ramjee, Mahadev","英国","Lancashire","Preston"],["Panthera Biopartners (Rochdale)","Radhakrishnan, Krishnakumar","英国","Manchester","Rochdale"],["Stockport Medical Group (NWEH)","Afshar, Arash","英国","Stockport","Stockport"],["Urmston Group Practice (NWEH)","Tong, Cliff","英国","Manchester","Urmston"],["Didsbury Medical Centre (NWEH)","Coupes, Andrew","英国","Manchester","Manchester"],["The Maples Medical Centre (NWEH)","Ahmad, Tasneem","英国","Manchester","Newall Green"],["Barlow Medical Centre (NWEH)","Allcock, Damian","英国","Manchester","Didsbury"],["Bridge House Medical Practice/Cheadle Hulme Medical Group (NWEH)","Richardson, Keith","英国","Cheadle","Cheadle"],["Guys and St Thomas's NHS Foundation Trust, London","Bafadhel, Mona","英国","London","London"],["St. Mary's Hospital","Wong, Ernie","英国","London","London"],["The Sides Medical Centre (NWEH)","Cribbin, Laurence","英国","Manchester","Swinton"],["Middlewood Partnership Bollington Medical Centre","Wilson, Pete","英国","Bollington","Bollington"],["Medicines Evaluation Unit (MEU)","Baxter, Caroline","英国","Manchester","Manchester"],["NIHR Patient Recruitment Centre Bradford","Saralaya, Dinesh","英国","Bradford","Bradford"],["Barts Health (St. Barts Hosptial)","Pfeffer, Paul","英国","London","London"],["Respiratory Biomedical Research Unit (BRU)","Gonem, Sherif","英国","Nottingham","Nottingham"],["University Hospital Birmingham NHS Foundation Trust","Sutton, Ben","英国","Birmingham","Edgbaston"],["HVIVO","Bevan, Melissa","英国","London","London"],["Centrum Dentystyczno Lekarskie Promedica Joanna Markiewicz","Brodowski, Arkadiusz","波兰","Bedzin","Bedzin"],["Department of General and Oncological Pulmonology, Medical University of Lodz","Ciebiada, Maciej","波兰","LODZ","LODZ"],["NZOZ Medica","Cygler, Jerzy","波兰","Gizycko","Gizycko"],["ATOPIA NZOZ Poradnie Specjalistyczne","Jasieniak-Pinis, Grazyna","波兰","Kraków","Kraków"],["SANTA FAMILIA PTG LODZ","Jedrzejczak, Mariola","波兰","LODZ","LODZ"],["NZOZ Heureka","Jonczak, Luiza","波兰","Piaseczno","Piaseczno"],["VILTIS MEDICA SPECJALISTYCZNA PRAKTYKA LEKARSKA AGATA KOT","Kot, Agata","波兰","Trzebnica","Trzebnica"],["Kucinska, Bozena","Velocity Clinical Research, Skierniewice","波兰","SKIERNIEWICE","SKIERNIEWICE"],["Madra-Rogacka, Danuta","Specjalistyczna Przychodnia Lekarska Alergo-Med sp. z o.o.","波兰","Poznan","Poznan"],["Centrum Medycyny Oddechowej Mróz SJ","Mroz, Robert","波兰","Bialystok","Bialystok"],["Centrum Badan Klinicznych","Napora, Piotr","波兰","Wroclaw","Wroclaw"],["Centrum Medyczne Pratia Katowice","Piaczek, Szymon","波兰","Katowice","Katowice"],["Przychodnia Alergologiczno-Pulmonologiczna Alergopneuma","Michnar, Marek","波兰","Lublin Voivodeship","Lublin"],["Makowskie Centrum Medyczne Hamernia Sp zoo","Bukowczan, Marcin","波兰","Maków Podhalański","Maków Podhalański"],["Centrum Medyczne All-med","Pulka, Grazyna","波兰","Krakow","Krakow"],["Ewa Springer Specjalistyczny Niepubliczny Zaklad Opieki Zdrowotnej Alergologia","Springer, Michal","波兰","Poznan","Poznan"],["Michal Bogacki - DOBROSTAN","Pisarczyk-Bogacka, Ewa","波兰","Wroclaw","Wroclaw"],["Ostrowieckie Centrum Medyczne s.c.","Cudzik Olech, Anna","波兰","Ostrowiec Swietokrzyski","Ostrowiec Swietokrzyski"],["Cenrum Nowoczesnych Terapiii","Bazan-Socha, Stanislawa","波兰","Krakow","Krakow"],["MCM Polimedica 2 Sp. z o.o.","Zakrzewski, Aleksander","波兰","Warszawa","Warszawa"],["Polimedica PTG Kielce","Latos, Anna","波兰","Kielce","Kielce"],["MICS Centrum Medyczne Torun","Brozek, Beata","波兰","Torun","Torun"],["EMED Centrum Uslug Medycznych","Tokarski, Siawomir","波兰","Rzeszow","Rzeszow"],["Comarch Healthcare","Mysior, Tomasz","波兰","Kracow","Kracow"],["Centro de Investigacion de especialidades medicas del Hospital de Chancay","Carbajal Paulet, Oscar","秘鲁","Lima","Chancay"],["Bio Ciencias Peru SRL","Chavez, William","秘鲁","Lima","Pueblo Libre"],["Hospital Militar Central “Luis Arias Schreiber / Centro de Investigación del Hospital Militar Central","Chavez Minano, Victoria","秘鲁","Lima","Jesús María"],["Clinica Internacional - Sede Lima","Guerreros, Alfredo","秘鲁","Lima","Cercado de Lima"],["Clínica Providencia / Centro de Investigación de Enfermedades Respiratorias","Iberico Barrera, Carlos Alberto","秘鲁","Lima","San Miguel"],["Hospital Naciolan Arzobispo Loayza","Herrera Flores, Edwin Hernando","秘鲁","Lima","Cercado de Lima"],["Sanna Clinica Belen","Gamarra Velarde, Ronal","秘鲁","Piura","San Ramon"],["Clinica San Pablo","Pena Villalobos, Alejandro Manuel","秘鲁","Lima","Surco"],["Hospital Nacional Cayetano Heredia","Salazar Ore, Danilo Joel","秘鲁","San Martin","San Martin de Porres"],["Asociacion Civil PORLASALUD","Velasquez, Nancy","秘鲁","Lima","Miraflores"],["Clinica Ricardo Palma","Villaran , Cesar","秘鲁","Lima","San Isidro"],["CLINICA LA LUZ","Zaga , Jose Antonio","秘鲁","Lima","Lince"],["Clínica El Golf","Sanchez , Ricardo","秘鲁","Lima","San Isidro"],["Centro de Atención de Enfermedades Cardiopulmonares","Campos Cerda, Ricardo","墨西哥","Jalisco","Guadalajara"],["UBAM Unidad Biomédica Avanzada Monterrey","Cantu Moreno, Daniel","墨西哥","Nuevo LeAn","Monterrey"],["ST LUCAS CLINICAL RESEARCH CENTER SA DE CV","CHE MORALES, JOSE LUIS","墨西哥","YucatAn","Merida"],["INSTITUTO VERACRUZANO EN INVESTIGACION CLINICA S.C.","García Toral, Rene","墨西哥","Veracruz de Ignacio de la Llave","Veracruz"],["INSTITUTO JALISCIENSE DE INVESTIGACION CLINICA","Hernandez Colin , Dante Daniel","墨西哥","Jalisco","Guadalajara"],["INVESTIGACION CLINICA A LA SALUD DE CORDOBA S.C.","Autrán Limón del Prado, Marco Antonio","墨西哥","Veracruz de Ignacio de la Llave","Cordoba"],["Centro de Investigación Médica Zapopan","Fletes Zepeda, Rafael","墨西哥","Jalisco","Zapopan"],["Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.","Reyes García, Edgar Alejandro","墨西哥","Ciudad de MAcxico","Mexico City"],["Unidad de Medicina Especializada SMA","Rosas, Mario Alberto","墨西哥","QuerActaro","San Juan del Río"],["Health Pharma Centro de investigación clínica","Sánchez Ríos, Carla Paola","墨西哥","Ciudad de MAcxico","Mexico City"],["Hospital Angeles Tijuana - Clinica de Sueno del Noroeste","Servin Diaz, Alberto Manuel","墨西哥","Baja California","Tijuana"],["Medical Care And Research S.A. DE C.V - Merida","Solís Martínez, Pedro Alejandro","墨西哥","YucatAin","Merida"],["Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V. (2)","Barajas Ugalde, Omar Daniel","墨西哥","Jalisco","Zapopan"],["Centro de Investigacion Medica y Reumatologia S.C","AGUILAR ARREOLA, JORGE ENRIQUE","墨西哥","Jalisco","Guadalajara"],["Instituto de Diabetes Obesidad y Nutrición S.C","Almicar, Pedro","墨西哥","Morelos","Cuernavaca"],["Unidad Medica para la Salud Integral (UMSI)","Posadas Valay, Rodolfo","墨西哥","Nuevo LeAn","San Nicolás de los Garza"],["Instituto de Investigaciones Aplicadas a la Neurociencia AC","Rodriguez Sarmiento, Luis Alfonso","墨西哥","Durango","Durango"],["Hospital Hispano","Morales Reyes, Maria Fernanda","墨西哥","Jalisco","Guadalajara"],["CIMER Centro Integral de Medicina Respiratoria","Altieri, Hector Hugo","阿根廷","TucumAin","San Miguel de Tucuman"],["CEMER","Bergna, Miguel","阿根廷","Buenos Aires","Florida, Vicente López"],["Instituto de Medicina Respiratoria IMER SRL","Cazaux, Alexis","阿根廷","CArdoba","Córdoba"],["Fundacion Respirar – Centro Médico Dra. De Salvo","De Salvo, Maria Christine","阿根廷","Buenos Aires","Ciudad Autonoma de Buenos Aires"],["Centro Médico INSARES – Instituto de Salud Respiratoria","Elias, Pedro Carlos","阿根廷","Mendoza","Mendoza"],["Centro Médico de Enfermedades Respiratorias (CEMER)","Fernadez Acquier, Mariano","阿根廷","Buenos Aires","Vicente López"],["Instituto Médico de la Fundación Estudios Clínicos","Gattolin, Gabriel","阿根廷","Santa Fe","ROSARIO"],["FUNDACION CIDEA","Maspero, Jorge","阿根廷","Buenos Aires","Buenos Aires"],["Centro Medico Dharma","Molina, Alicia Beatriz","阿根廷","Mendoza","Mendoza"],["CINME - Centro de Investigacion Metabolica","Saenz, Gonzalo","阿根廷","Ciudad Autonoma de Buenos Aires","Ciudad Autónoma de Buenos Aires"],["Fundacion Scherbovsky","Saez Scherbovsky, Pablo Efrain","阿根廷","Mendoza","Mendoza"],["Investigaciones en Patologias Respiratorias","Rojas, Ramon Angel","阿根廷","TucumAin","San Miguel de Tucuman"],["Centro de Investigaciones Medicas Mar del Plata (CIM-MDP)","Taborda, Jorge","阿根廷","Buenos Aires","Mar del Plata"],["CARE – Centro de Alergia y Enfermedades Respiratorias","Piza, Hernan Daniel","阿根廷","Buenos Aires","Ciudad Autónoma de Buenos Aires"],["Instituto Ave Pulmo - Fundación Enfisema","Wehbe, Luis","阿根廷","Buenos Aires","Mar del Plata"],["Instituto de Investigaciones en Alergia y Enfermedades Respiratorias (INAER)","Yanez, Anahi","阿根廷","Buenos Aires","Ciudad Autónoma de Buenos Aires"],["CEMEC- Centro Multidisciplinar de Estudos Clínicos","Pez, Andréia","巴西","SA￡o Paulo","Sao Bernardo do Campo"],["CMPC - Clinica de Alergia","Antila, Martti","巴西","SA￡o Paulo","Sorocaba"],["Instituto do Coracao do Hospital das Clínicas da Faculdade de Medicina da USP","Athanazio, Rodrigo","巴西","SA￡o Paulo","Sao Paulo"],["Hospital Sao Lucas da PUCRS","Blanco, Daniela","巴西","Rio Grande do Sul","Bairro Jardim Botanico"],["CEPES / FMABC","Fiss, Elie","巴西","SA￡o Paulo","Santo André"],["HOSPITAL DIA DO PULMAO","Lima, Marina","巴西","Santa Catarina","Blumenau"],["Praxis Pesquisa Médica","Bacci, Marcelo","巴西","SA￡o Paulo","Santo Andre"],["SVRI - Hospital Santa Casa de Santos","Macedo, Alex Goncalves","巴西","SA￡o Paulo","Santos"],["WM Clinica Pneumológica","de Mattos, Waldo Luis Leite Dias","巴西","Rio Grande do Sul","Porto Alegre"],["Science Valley Research Institute (Campo Largo)","Rivabem Jr, Dalton Luiz","巴西","SA￡o Paulo","Campo Largo"],["Irmandade da Santa Casa de Misericórdia de Porto Alegre","Rubin, Adalberto Sperb","巴西","Rio Grande do Sul","Porto Alegre"],["HCFMRP - Hospital das Clínicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo","Vianna, Elcio","巴西","SA￡o Paulo","Ribeirao Preto"],["Healthy Medical Center S.A.S. (Colombia)","Bastidas, Alirio","哥伦比亚","Cundinamarca","Zipaquirá"],["Fundacion Santa Fe de Bogota","Garcia Morales, Olga Milena","哥伦比亚","Bogota","Bogota"],["Mediservis del Tolima IPS","Rios Sossa, Carlos Enrique","哥伦比亚","Ibague","Ibague"],["Clinica de la Costa SAS","Gomez Giraldo, Luisa Maria","哥伦比亚","Barranquilla","Barranquilla"],["Instituto Neumologico del Oriente","Cano, Diana Jimena","哥伦比亚","Santander","Floridablanca"],["Hospital of The University of Occupational and Environmental Health, Japan","Yatera, Kazuhiro","日本","Fukuoka Prefecture","Kitakyushu"],["Japanese Red Cross Medical Center","Izumo, Takehiro","日本","Tokyo","Shibuya-ku"],["Yokohama City University Hospital","Hara, Yu","日本","Kanagawa Prefecture","Yokohama"],["Medical corporation Syureikai Tohno Chuo Clinic","Ohbayashi, Hiroyuki","日本","Gifu Prefecture","Mizunami"],["Yamaguchi University Hospital","Oishi, Keiji","日本","Yamaguchi Prefecture","Ube City"],["Center Hospital of the National Center for Global Health and Medicine","Terada, Junko","日本","Tokyo","Shinjuku-ku"],["Fujita Health University Bantane Hospital","Hirose, Masahiro","日本","Aichi Prefecture","Naogya"],["Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai","Shinkai, Masaharu","日本","Tokyo","Shinagawa"],["NHO Osaka Toneyama Medical Center","Kida, Hiroshi","日本","Toyonaka","Toyonaka"],["Kirigaoka Tsuda Hospital","Kawano, Tetsuya","日本","Fukuoka Prefecture","Kitakyushu"],["Tokyo Medical University Hospital","Kono, Yuta","日本","Tokyo","Shinjuku-ku"],["Toranomon Hospital","Tamaoka, Meiyo","日本","Tokyo","Minato-ku"],["National Hospital Organization Tokyo National Hospital","Oshima, Nobuharu","日本","Tokyo","Kiyose"],["Matsusaka Municipal Hospital","Hataji, Osamu","日本","Mie Prefecture","Matsusaka"],["Shizuoka General Hospital","Shirai, Toshihiro","日本","Shizuoka Prefecture","Shizuoka"],["Shimane University Hospital","Hamaguchi, Megumi","日本","Shimane Prefecture","Izumo"],["Fukuwa Clinic","Fukushima, Yasushi","日本","Tokyo","Chuo-ku"],["Okayama Rosai Hospital","Fujimoto, Nobukazu","日本","Okayama Prefecture","Okayama-shi"],["Toyama Prefectural Central Hospital","Taniguchi, Hirokazu","日本","Toyama Prefecture","Toyama"],["Kobe City Hospital Organization Kobe City Medical Center West Hospital","Kaneko, Masahiro","日本","HyAgo Prefecture","Kobe"],["Saga University Hospital","Takahashi, Koichiro","日本","Saga Prefecture","Saga"],["Ibarakihigashi National Hospital","Saito, Takefumi","日本","Ibaraki Prefecture","Naka-gun"],["University of Fukui Hospital","Ishizuka, Tamotsu","日本","Fukui Prefecture","Yoshida-gun"],["National Hospital Organization Fukuoka National Hospital","Fukushima, Takehito","日本","Fukuoka Prefecture","Fukuoka"],["JCHO Kyuushu Hospital","Harada, Taishi","日本","Fukuoka Prefecture","Kitakyushu"],["National Hospital Organization - Kasumigaura Medical Center","Kikuchi, Norihiro","日本","Ibaraki Prefecture","Tuchiura"],["Kagoshima University Hospital","Hideo, Mitsuyama","日本","Kagoshima Prefecture","Kagoshima"],["Japan Agricultural Cooperatives Kochi Hospital","Shinohara, Tsutomu","日本","KAchi Prefecture","Nangoku"],["Niigata University Medical & Dental Hospital","Koya, Toshiyuki","日本","Niigata Prefecture","Niigata-shi"],["Fujieda Municipal General Hospital","Koshimizu, Naoki","日本","Shizuoka Prefecture","Fujieda"],["Toyama University Hospital","Inomata, Minehiko","日本","Toyama Prefecture","Toyama"],["Nihon University Itabashi Hospital","Maruoka, Shuichiro","日本","Tokyo","Itabashi"],["Keio University Hospital","Miyata, Jun","日本","Tokyo","Shinjuku-ku"],["Kindai University Hospital","Matsumoto, Hisako","日本","Osakasayama-shi","Osakasayama-shi"],["Tokai University Hospital","Asano, Koichiro","日本","Kanagawa Prefecture","Isehara"],["Nissei Hospital","Sugaya, Fumiko","日本","HokkaidA Prefecture","Sapporo-city"],["Kochi Medical School Hospital","Onishi, Hiroshi","日本","KAchi Prefecture","Nankoku-shi"],["Nagoya city university Hospital","Niimi, Akio","日本","Aichi Prefecture","Nagoya"],["Tokyo Women's Medical University","Tagaya, Etsuko","日本","Tokyo","Shinjuku-ku"],["Saitama Medical University Hospital","Nagata, Makoto","日本","Saitama Prefecture","Iruma-gun"],["Terada Clinic Respiratory Medicine & General Practice","Terada, Kunihiko","日本","HyAgo Prefecture","Himeji-shi"],["Hiroshima Prefectural Hospital","Ishikawa, Nobushia","日本","Hiroshima Prefecture","Hiroshima City"],["Asahikawa Medical University Hospital","Minami, Yoshinori","日本","HokkaidA Prefecture","Asahikawa City"],["Hallym University Medical Center (HUMC) - Sacred Heart Hospital (SHH) - Pulmonology and Allergy Center","Kim, Joo-Hee","韩国","Gyeonggi Province","Anyang-Si"],["SMG-SNU Boramae Medical Center","Kim, Deog Kyeom","韩国","Seoul","Dongjak-gu"],["Jeonbuk National University Hospital","Lee, Yong Chul","韩国","Jeonju-si","Jeonju-si"],["Inje University Haeundae Paik Hospital","Park, Chan Sun","韩国","Busan","Haeundae-gu"],["The Catholic University of Korea - Seoul St. Mary's Hospital (Kangnam St. Mary's Hospital)","Lee, Sook-young","韩国","Seoul","Seocho-gu"],["Yeungnam University Medical Center","Lee, Kwan-Ho","韩国","Daegu","Nam-gu"],["Ajou University Hospital","Park, Joo Hun","韩国","Gyeonggi Province","Suwon-si"],["Korea University Guro Hospital","Min, Kyung-hoon","韩国","Seoul","Guro-gu"],["Konkuk University Medical Center","Yoo, Kwang-Ha","韩国","Seoul","Gwangjin-gu"],["Seoul National University Hospital (SNUH)","Lee, Chang-Hoon","韩国","Seoul","Jongno-gu"],["The Catholic University of Korea - Yeouido St. Mary's Hospital","Yoon, Hyoung-Kyu","韩国","Seoul","Yeongdeungpo-gu"],["Hanyang University Hospital","Kim, Sang-Heon","韩国","Seoul","Seongdong-gu"],["Gachon Gil Medical Center","Lee, Sang-Pyo","韩国","Incheon","Namdong-gu"],["Kyung Hee University Hospital at Gangdong","An, Jin","韩国","Seoul","Seoul"],["Medical Center New Rehabilitation Center Ltd","Dimov, Dimo","保加利亚","Stara Zagora Province","Stara Zagora"],["SHATPPD Dr.Dimitar Gramatikov Ruse","Metev, Hristo","保加利亚","Ruse Province","Ruse"],["Medical Center Hera EOOD","Nedeva, Denislava","保加利亚","Sofia Province","Sofia"],["Multiprofile Hospital for Active Treatment Dr. Stamen Iliev AD","Nikolcheva-Todorova, Lidiya","保加利亚","Montana Province","Montana"],["Multiprofile Hospital for Active Treatment Sliven (MMA Sofia)","Petrova, Vanushka","保加利亚","Silven","Silven"],["Specialized Hospital for Active Treatment of Pulmonary Diseases - Pernik","Petrova, Galina","保加利亚","Pernik Province","Pernik"],["MC IRN Medical","Lund, Borislav","保加利亚","Sofia Province","Sofia"],["MC Comac Medical","Popova, Iva","保加利亚","Sofia Province","Krasno selo District"],["Medical Center “Sveti Ivan Rilski”","Iliev, Ivo","保加利亚","Vidin Province","Vidin"],["MHAT St. Ekaterina EOOD","Atanasov , Todor","保加利亚","Dimitrovgrad","Dimitrovgrad"],["Medical Center for Outpatient Care, Preventsia 2000","Zhelyazkova, Yanitsa","保加利亚","Stara Zagora Province","Stara Zagora"],["University First MHAT-Sofia Sv Yoan Krastitel EAD","Kirkova, Ginka","保加利亚","Sofia Province","Sofia"],["SHCTRPPD “Sveta Petka Bulgarska” EOOD","Avramov, Rumen","保加利亚","Velingrad","Velingrad"],["MC Zdrave 1","Tiholov, Rumen","保加利亚","Kozloduy","Kozloduy"],["Medical Center Medconsult Pleven","Todorova, Mariya","保加利亚","Pleven Province","Pleven"],["MC “Etika – ASOMC” OOD","Valkanova, Iliyana","保加利亚","Plovdiv Province","Plovdiv"],["Multi-Profile Hospital for Active Treatment (MHAT) Dr.","Lalov, Grigor","保加利亚","Smolyan Province","Smolyan"],["MHAT “St. Panteleimon” LTD","Parev, Atanas","保加利亚","Plovdiv Province","Plovdiv"],["Medical Center Medconsult Pleven (Lovech branch)","Bozhkov, Lyubomir","保加利亚","Sofia Province","Lovech"],["Medical center Hera - Montana branch","Petrova- Pintova, Vedelinka","保加利亚","Montana Province","Montana"],["Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD","Yankulova, Mariana","保加利亚","Sofia Province","Sofia"],["Diagnostic consultative center 1 - Sliven Ltd.","Doseva , Dina","保加利亚","Sliven Province","Sliven"],["Ternopil Municipal City Hospital #2, therapeutic department #1","Andreychyn, Serhiy","乌克兰","Ternopilska oblast","Ternopil"],["Municipal Institution Chernivtsi Regional Clinical Hospital","Kovalenko, Svitlana","乌克兰","Chernivtsi","Chernivtsi"],["Private Small-Scale Enterprise Medical Center","Demchuk, Anna","乌克兰","Vinnytska oblast","Vinnytsia"],["Ivano-Frankivsk Regional Phthisiology-Pulmonology Center of Ivano-Frankivsk regional council","Ostrovskyy, Mykola","乌克兰","Ivano-Frankivska oblast","Ivano-Frankivsk"],["Municipal Institution “Central City Hospital #1 of Zhytomyr City”, Consultative and Treatment Department","Vyshnyvetskyy, Ivan","乌克兰","Zhytomyrska oblast","Zhytomyr"],["SO","Prymushko, Nataliia","乌克兰","Kyiv","Kyiv"],["Communal Non-Commercial Enterprise","Slepchenko, Nataliia","乌克兰","Vinnytsia","Vinnytsia"],["Regional clinical hospital.State university","Gerych, Petro","乌克兰","Ivano-Frankivska oblast","Ivano-Frankivsk"],["SO","Moskalenko, Svitlana","乌克兰","Kyiv","Kyiv"],["Medical Center “Universal clinic “Oberig” LLC “Kapital”","Babanina, Tetiana","乌克兰","Kyivska oblast","Kyiv"],["National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky NAMS of Ukraine","Kuryk, Lesia","乌克兰","Kyiv","Kyiv"],["State Institution","Shvaiko, Liudmyla","乌克兰","Kyiv","Kyiv"],["Treatment and diagnostic center","Varunkiv, Oleksandr","乌克兰","Ivano-Frankivska oblast","Ivano-Frankivsk"],["Kyiv Railway Clinical Hospital #2","Gundertaylo, Bogdan","乌克兰","Kyiv","Kyiv"],["Communal enterprise","Yakovenko, Oleh","乌克兰","Lutsk","Lutsk"],["Communal non-profit enterprise","Myhovych, Vira","乌克兰","Ivano-Frankivska oblast","Ivano-Frankivsk"],["Medical center of the limited liability company","Donets, Dmytro","乌克兰","Kyiv","Kyiv"],["Edelweiss Medics LLC","Vasylenko, Kateryna","乌克兰","Kyiv","Kyiv"],["Vinnytsia National Medical University. N. I. Pirogov","Zhebel, Vadym","乌克兰","Vinnytska oblast","Vinnytsia"],["Bukovinian State Medical University (BSMU)","Ilashchuk, Tetiana","乌克兰","Chernivtsi","Chernivtsi"],["Vinnytsia Regional Clinical Hospital Named After N.I.Pirogov","Stanislavchuk, Mykola","乌克兰","Vinnytsya","Vinnytsya"],["University Clinical Center Kragujevac, Clinic for Pulmonology","Cupurdija, Vojislav","塞尔维亚","Kragujevac","Kragujevac"],["University Chilren Hospital Belgrade","Jovicic, Nevena","塞尔维亚","Belgrade","Belgrade"],["General Hospital Valjevo","Sofronic, Dejan","塞尔维亚","Valjevo","Valjevo"],["University Clinical Center Nis, Pulmonary Diseases Clinic","Stankovic, Ivana","塞尔维亚","Nis","Nis"],["University Clinical Center of Serbia, Clinic of Pulmonology","Stjepanovic, Mihailo","塞尔维亚","Belgrade","Belgrade"],["Clinical Hospital Center (CHC) Zemun","Vukcevic, Miodrag","塞尔维亚","Belgrade","Belgrade"],["Municipal Institute for Lung Diseases and Tuberculosis","Zujovic, Dejan","塞尔维亚","Belgrade","Belgrade"],["Institut Za Plucne Bolesti Vojvodine (The Institute For Pulmonary Diseases of Vojvodina)","Zvezdin, Biljana","塞尔维亚","Sremska Kamenica","Sremska Kamenica"],["Institute for Child and Youth Health Care of Vojvodina","Vilotijevic-Dautovic, Gordana","塞尔维亚","Novi Sad","Novi Sad"],["Zvezdara University Medical Center- Dept of Pulmonology, Allergology and Clinical Immunology","Petrovic-Stanojevic, Natasa","塞尔维亚","Belgrade","Belgrade"],["General hospital Uzice","Radojevic, Zorica","塞尔维亚","Uzice","Uzice"],["Municipal Institute for Lung Diseases and Tuberculosis Department for adult patients","Radulovic, Vesna","塞尔维亚","Belgrade","Belgrade"],["General Hospital Veles","Arsov, Gjorgi","马其顿","Veles Municipality","Veles"],["8mi Septemvri","Kochovska Kamchevska, Nade","马其顿","Greater Skopje","Skopje"],["University Clinic of Pulmology and Allergology","Dokic, Dejan","马其顿","Greater Skopje","Skopje"],["PHI General Hospital Strumica","Gjorgiev, Slavcho","马其顿","Strumica Municipality","Strumica"],["PHI Clinical Hospital Stip","Josifovska, Svetlana Tofilovska","马其顿","Stip","Stip"],["PHI Institute for Lung Diseases and Tuberculosis","Zeynel, Sead","马其顿","Greater Skopje","Skopje"],["FDI Clinical Research","Ramos, Cristina","波多黎各","San Juan","San Juan"],["Allianze Pulmonary Research, LLC","Aranda, Alvaro","波多黎各","Guaynabo","Guaynabo"],["Ponce Medical School Foundation, Inc","Aleman-Ortiz, Jesse","波多黎各","Ponce","Ponce"],["Saint George Hospital University Medical Center (SGHUMC)","Waked, Mirna","黎巴嫩","Beirut","Beirut"],["Hotel-Dieu de France Hospital","Habr, Bassem","黎巴嫩","Beirut Governorate","Ashrafieh"],["Nini Hospital","Chahine, Zahia","黎巴嫩","Tripoli","Tripoli"],["Ain wazein Medical village","Sleiman, Wissam","黎巴嫩","Mount Lebanon Governorate","Al Shouf"],["Rafik Hariri University Hospital","Shahin, Hani","黎巴嫩","Beirut Governorate","Jnah"],["American University of Beirut","Bou Khalil, Pierre","黎巴嫩","Beirut Governorate","Beirut"],["“Clinic-LJ” LTD","Bzhalava, Maka","格鲁吉亚","Kutaisi","Kutaisi"],["Center of Allergy and Immunology","Gotua, Maia","格鲁吉亚","Tbilisi","Tbilisi"],["Institute of Clinical Cardiology","Maisuradze, Irma","格鲁吉亚","Tbilisi","Tbilisi"],["Diacor LTD","Sherozia, Elene","格鲁吉亚","Tbilisi","Tbilisi"],["Aleksandre Aladashvili Clinic LLC","Kokoshvili, Nana","格鲁吉亚","Tbilisi","Tbilisi"],["TSMU & Ingorokva High Medical Technologies University Clinic","Chelidze, Kakhaber","格鲁吉亚","Tbilisi","Tbilisi"],["High Technology Hospital Medcenter LLC","Mamuladze, David","格鲁吉亚","Batumi","Batumi"],["ALLERGY XXI CENTURY","Rodonaia, Ekaterine","格鲁吉亚","Tbilisi","Tbilisi"],["Acad. G. Chapidze Emergency Cardiology Center","Maglakelidze, Tamaz","格鲁吉亚","Tbilisi","Tbilisi"],["LTD","Machavariani, Ketevan","格鲁吉亚","Tbilisi","Tbilisi"]]

序号	机构名称	主要研究者	国家	省（州）	城市

[["北京大学第三医院医学科学研究伦理委员会","同意","2024-08-05"]]

序号	名称	审查结论	批准日期/备案日期

进行中（尚未招募）

目标入组人数	国内: 100 ； 国际: 1395 ；
已入组人数	国内: 登记人暂未填写该信息； 国际: 656 ；
实际入组总人数	国内: 登记人暂未填写该信息； 国际: 登记人暂未填写该信息；

第一例受试者签署知情同意书日期	国内：登记人暂未填写该信息；     国际：2023-01-30；
第一例受试者入组日期	国内：登记人暂未填写该信息；     国际：2023-02-23；
试验完成日期	国内：登记人暂未填写该信息；     国际：登记人暂未填写该信息；